O76997

PR
Gene name
Protein name
Putative neurotrophin receptor LTRK 1
Names
Species
Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-146 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

664-689 (Activation loop from InterPro)

Target domain

504-789 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O76997

Entry ID Method Resolution Chain Position Source
AF-O76997-F1 Predicted AlphaFoldDB

No variants for O76997

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O76997

No associated diseases with O76997

1 regional properties for O76997

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 434 - 443 IPR017972

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

3 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRGPRRFRLW TRANVLTVIS ILTSILSGAG CSPLSQLPSD NPAHVGVQDG VTTERVDRSK
70 80 90 100 110 120
NHRNTTASSG AHRVTSGEPL GDRVTTRSTT APDQVPGDAS RNTTMAGTKC SLQVDLSTFA
130 140 150 160 170 180
CPADCQCNAT SEGMVVSCVT PDTLREFPVI AREVARAVIK LELRGQSKLT SLKTELKFFT
190 200 210 220 230 240
CLKHLTIENC GLNNIQGIAF KTLTSLETIN LRHNHLTEFP QELLRTLNLR ELWLEGNALT
250 260 270 280 290 300
CSCTNLWLRS VDVAADRSEM TCSTRDGVSK MKMTQFKCEP CGIPDIRNMT LVFEPKNGMF
310 320 330 340 350 360
LLRFVISGCP KPKIDLLRNH HHVLRSGSSQ FKLTDFKSEF NGQVVTGTIT ILPHMETSQT
370 380 390 400 410 420
TYVLTAVNSK GQANQTFHLY DQTTPASSIH IPLSNIPPRI SSATTPRASP TEDFGPQTQV
430 440 450 460 470 480
ILPVVGVVIL LISAVFIIYL CQRAKHRSHA RQRCKKALLD KKFNEFQEGV PLTGLQLVDN
490 500 510 520 530 540
PNYNLTKKKH VATTCPKTVR LQTILLMRVI GEGAFGRVFL GTCAHLIQKN EFAIVAVKTL
550 560 570 580 590 600
KGSCSDSLKR DFEREAEMLA TIEHANIVTF YGVCTESDQW MMIFEFMENG DLNKYLRMHG
610 620 630 640 650 660
PDAAFLKDRD SMDSDEGQLT REQLMKIVLQ IASAMEYLAL QHFVHRDLAT RNCLVGCDLV
670 680 690 700 710 720
VKLGDFGMSR DVYTTDYYRV EGTAMLPVRW MPPESIIYRT FTTESDVWSF GVTLWEVFTY
730 740 750 760 770 780
GKQPWFEYSN SEVIEHIKNS RTLKRPPRTC TDGVYRVMQG CWKPNPQDRL TMKDIAELLR
790
EEVSGDPVYI DIIA