O76819

PR
Gene name
HMGR
Protein name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Names
HMG-CoA reductase
Species
Agrotis ipsilon (Black cutworm moth)
KEGG Pathway
EC number
1.1.1.34: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

315-426 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O76819

Entry ID Method Resolution Chain Position Source
AF-O76819-F1 Predicted AlphaFoldDB

No variants for O76819

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O76819

No associated diseases with O76819

4 regional properties for O76819

Type Name Position InterPro Accession
domain Sterol-sensing domain 62 - 217 IPR000731
conserved_site Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site 590 - 604 IPR023076-1
conserved_site Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site 746 - 753 IPR023076-2
conserved_site Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site 799 - 812 IPR023076-3

Functions

Description
EC Number 1.1.1.34 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Endoplasmic reticulum membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
hydroxymethylglutaryl-CoA reductase (NADPH) activity Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.

2 GO annotations of biological process

Name Definition
coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKVWGAHGEF CARHQWEVIV ATLALLACAA SVERNGPGNR SEHCAGWARA CPGLEAEYQA
70 80 90 100 110 120
ADAVIMTFVR CAALLYAYYQ ISNLHKIASK YLLIIAGVFS TFASFIFTSA VASLFWSELA
130 140 150 160 170 180
SIKDAPFLFL LVADVARGAR MAKAGWSAGE DQGKRVGRAL ALLGPTATLD TLLAVLLVGV
190 200 210 220 230 240
GALSGVPRLE HMCTFACLAL LVDYLVFVTF YPACLSLVAD FASGRKEMSP DSPFSEADLK
250 260 270 280 290 300
PNPVVQRVKM IMAAGLLCVH LTSRWPWSSD NGIIEGPTDT LTPTSNDNIL LHSYVKWFSV
310 320 330 340 350 360
SADYIVIATL LCALIIKFVF FEEQRNWVID MNDMTVKEVV QEQARSKPKF SVGDDSNSEV
370 380 390 400 410 420
STQTEGVLED EWPTLSPSSS AAKLNSKKRP MAECLEIYRS EGACVSLSDE EVVMLVEQSH
430 440 450 460 470 480
IPLHRLEAVL GDPLRGVRLR RKVVGARFQT ELAIKQLPYL NYDYSKVLNA CCENVIGYVG
490 500 510 520 530 540
VPVGYAGPLV VDGKPYMIPM ATTEGALVAS TNRGAKAIGI RGVTSVVEDV GMTRAPAIKL
550 560 570 580 590 600
PNVVRAHECR QWIDNKDNYA VIKEAFDSTS RFARLQEIHI GVDGATLYLR FRATTGDAMG
610 620 630 640 650 660
MNMVSKGAEN ALKLLKNYFP DMEVISLSGN YCSDKKAAAI NWVKGRGKRV VCETTITSDS
670 680 690 700 710 720
LRTIFKTDAK TLARCNKIKN LSGSALAGSI GGNNAHAANM VTAIYIATGQ DPAQNVTSSN
730 740 750 760 770 780
CSTNMEVCGE NGEDLYVTCT MPSLEVGTVG GGTILTGQGA CLDILGVKGA GARPAENSAR
790 800 810 820 830
LASLICATVL AGELSLMAAL VNSDLVKSHM RHNRSTVNVQ VQAENITLKV PTL