Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

174-196 (Activation loop from InterPro)

Target domain

39-324 (Protein kinase domain)

Relief mechanism

Assay

Autoinhibited structure

Activated structure

1 structures for O76484

Entry ID Method Resolution Chain Position Source
AF-O76484-F1 Predicted AlphaFoldDB

No variants for O76484

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O76484

No associated diseases with O76484

3 regional properties for O76484

Type Name Position InterPro Accession
domain Protein kinase domain 39 - 324 IPR000719
active_site Serine/threonine-protein kinase, active site 152 - 164 IPR008271
binding_site Protein kinase, ATP binding site 45 - 68 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTMAVPSRAR VYADVNSQRP REYWDYESYV VDWGNQEDYQ LVRKLGRGKY SEVFEAINIT
70 80 90 100 110 120
NNEKCVVKIL KPVKKKKIKR EIKILENLRG GTNIITLQAV VKDPVSRTPA LIFEHVNNTD
130 140 150 160 170 180
FKQLYQTLSD YDIRYYLYEL LKALDYCHSM GIMHRDVKPH NVMIDHDHRK LRLIDWGLAE
190 200 210 220 230 240
FYHPGQDYNV RVASRYFKGP ELLVDYQMYD YSLDMWSLGC MLASMIFRKE PFFHGHDNYD
250 260 270 280 290 300
QLVRIAKVLG TEELFEYLDK YHIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF
310 320 330 340 350
LDRLLRYDHY ERYTAREAMD HPYFYPIVKE QGRMVSSNSP TPNALQGPIS TTE