O76332

PR
Gene name
TERT
Protein name
Telomerase reverse transcriptase
Names
Telomerase catalytic subunit, Telomerase subunit P133
Species
Oxytricha trifallax (Sterkiella histriomuscorum)
KEGG Pathway
EC number
2.7.7.49: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O76332

Entry ID Method Resolution Chain Position Source
AF-O76332-F1 Predicted AlphaFoldDB

No variants for O76332

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O76332

No associated diseases with O76332

2 regional properties for O76332

Type Name Position InterPro Accession
domain Reverse transcriptase domain 602 - 956 IPR000477
domain Telomerase ribonucleoprotein complex - RNA-binding domain 460 - 593 IPR021891

Functions

Description
EC Number 2.7.7.49 Nucleotidyltransferases
Subcellular Localization
  • Nucleus
  • Chromosome, telomere
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
metal ion binding Binding to a metal ion.
telomerase RNA reverse transcriptase activity Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSAKKPVQSK LNIGNPTIPV TSNRSTAPKP VPGQPQFVNQ EKKQQSQNTT TGAFRSNQNN
70 80 90 100 110 120
ANSGGNGNFE LDDLHLALKS CNEIGSAKTL FCFFMELQKI NDKIPSKKNT ELIKNDPQFQ
130 140 150 160 170 180
YFCHNTILCT EQSYDEKTIE KLAKLEYKLE YKNSYIDMIS KVIKELLIEN KLNKLQTFGY
190 200 210 220 230 240
KLVNNEFGNQ NHLGMMQQNQ DSSHNSNFMV KCDYINLNKQ CMITKNWEKV YFYLGDHLFM
250 260 270 280 290 300
HIYKEYMIFL KTRDESLVQI SGTNIFCYLN EKLGRLQAAF YEGPNKNAAN SAAQGSNPEA
310 320 330 340 350 360
NDLISAEQRK INTAIVMKKT HKYNIKAADE SYLTNQEKGF WDDQIKRNRL FYCAHQNRFF
370 380 390 400 410 420
QKHILNSKTL SQQQIRDNIY KEVFGFNRVR AELKGKVMSI IEQVIVNQKK FDFKYYLSKN
430 440 450 460 470 480
CPLPENWKNL KKSFLEDAAV SGELRGQVFR QLFEYQQDQR QISNFLTEFV ANVFPKNFLE
490 500 510 520 530 540
GKNKKIFNKK MLQFVKFNRF ESFTKISLLN KFRVNEVSWL SFKCKDENKK FFMNENEHVF
550 560 570 580 590 600
FKVLKWVFED LAITLMRCYF YSTEKAKEYQ RIFYYRKNIW NMIMRLSIDD LLKQNLKQVE
610 620 630 640 650 660
KKEMRIFCES QNFAPGKLRL IPKGDTFRPI MTFNRKIPNQ VGKFQSRMTT NNKLQTAHMM
670 680 690 700 710 720
LKNLKSKMFK HSFGFAVFNY DDIMKRYENF VQKWKQINSP KLYFVAMDIE KCYDNVDCER
730 740 750 760 770 780
VVNFLQKSDL MDKEYFILNT FVLKRKNNII VERSNFRKLP IKQYFRYKFQ KIGIDGSSYP
790 800 810 820 830 840
TLFEILEDEF NDLNMKRTII VEQEQRKKFP KNDLLQPVLK ICQNNYVTFN KKQYKQMKGI
850 860 870 880 890 900
PQGLCVSYIL SSFYYANLEE NALQFLRKES MDPEKPEINL LMRLTDDYLL MTTEKNNAML
910 920 930 940 950 960
FIEKLYQLSL GNFFKFHMKK LKTNFALNLQ KIGCTNTTQD IDSINDDLFH WIGISIDIKT
970 980 990 1000 1010 1020
LNIIQNINIK KEGILCTLNV NMQTNESILW LKKKLKSFLM NNISFYFKST INTKQFANIT
1030 1040 1050 1060 1070 1080
LSKLYIAAAE KYVACCQEFK RFHENTSLGG QNIDIKIIHI IYVVIRSFFK YLVCNVKSPV
1090 1100 1110 1120 1130
FERDDYQQFF IYSLKFFITR FKQQKNEFAG VYKILKAKEK KLEVAKIEFQ IQ