O76187

PR
Gene name
darA (DDB_G0288771)
Protein name
Darlin
Names
Armadillo-like protein A
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0288771
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

530-608 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O76187

Entry ID Method Resolution Chain Position Source
AF-O76187-F1 Predicted AlphaFoldDB

No variants for O76187

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O76187

No associated diseases with O76187

No regional properties for O76187

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O76187

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
small GTPase binding Binding to a small monomeric GTPase.

2 GO annotations of biological process

Name Definition
aggregation involved in sorocarp development The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEEIQKLINE LGGSQYKDKD TEHYSEEAVE LLIKKIDNKS KGKTVIESNT LIYKTLADWS
70 80 90 100 110 120
KVEDNRETII RSPSNVIEKT FQLFEFLLPN GVETLNTDTT VEQSELFSMV CRLLGNLTYE
130 140 150 160 170 180
NAPNREFIFD KTPSILKYIS SFVSQTKYQS LQRTSCAAIA NLSSETDFIQ LEFFKLGVVS
190 200 210 220 230 240
ILIDLICREG TTDEVNQMAI KAFNNLVDNE NTQVDIHFKE IHRLLGQLKK SLNKEGYYEN
250 260 270 280 290 300
SFANDLVSSL STLSLNKDLQ KEILKEGFLN DLIELIEESN VHREMINQFE DDDIEKDKDI
310 320 330 340 350 360
SIAPSTSELI FKLADNDDYR QYFYNKERDG NDANNILDRM IKIMTSPPPA YKDGDSKAQL
370 380 390 400 410 420
KALDVAKVKK NITKTIALCS LEDDVIDKFI KTPKIFVDLL VDTEDTERIV NGEMIIGNLA
430 440 450 460 470 480
RSEPNCRLLN SYNVIELIAD IMKKFPNFQP IQHLGLSSIR NLTLPTINKG FKPSSTLMED
490 500 510 520 530 540
VVFNSKVHNQ VIQFAALSLI KNFIGCDQSN LKLFLEFPNA LQSLLDLANG RVPASMDDES
550 560 570 580 590 600
DQQEQLQLDD AKIQEIEEKF EEKEKTIEKT DEKTDEKTNE KKQSKKDMRV IYEATRLLLR
610 620 630 640 650 660
FLDNSELSNH QEKMKQLIEE SVEPFFSLLQ SPFPILQVEG AKGLVLLIKH DKQLFLSRPS
670 680 690 700 710 720
WVKDLVEVLS LSIIPFQQLS REQSTITTDP NHQKLIAQIQ SNCNFSTELQ NVILSNIFYN
730 740 750 760
FSLDESICKK MKDQNVISEL KTLKSKQDAP QSLTNLIQKI LVQLTI