AiPD: Autoinhibited Protein Database

O76061

Gene name	STC2
Protein name	Stanniocalcin-2
Names	STC-2, Stanniocalcin-related protein, STC-related protein, STCRP
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8614
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-70 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for O76061

Entry ID	Method	Resolution	Chain	Position	Source
7Y5Q	EM	380 A	C	1-302	PDB
8A7D	EM	306 A	P	44-210	PDB
8A7E	EM	502 A	A/P	44-211	PDB
8HGH	EM	416 A	C/G	1-302	PDB
AF-O76061-F1	Predicted				AlphaFoldDB

214 variants for O76061

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs778989259 CA3564119	2	C>G		No	ClinGen ExAC gnomAD
rs778989259 CA362217355	2	C>S		No	ClinGen ExAC gnomAD
rs200255935 CA3564118	4	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1421083078 CA362217325	7	G>S		No	ClinGen gnomAD
CA3564117 rs753263968	7	G>V		No	ClinGen ExAC TOPMed gnomAD
CA362217307 rs1431828027	9	F>C		No	ClinGen gnomAD
TCGA novel	13	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3564116 rs777520249	13	A>V		No	ClinGen ExAC gnomAD
CA362217259 rs1192348754	17	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs201354731 CA3564115	17	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1206826522 CA362217227	21	P>L		No	ClinGen TOPMed
CA362217226 rs1488716158	22	A>T		No	ClinGen gnomAD
CA362217223 rs1260231898	22	A>V		No	ClinGen TOPMed
CA3564113 rs759825929	23	R>G		No	ClinGen ExAC gnomAD
CA3564112 rs759825929	23	R>W		No	ClinGen ExAC gnomAD
COSM1227840 rs780730599 CA132537096	24	G>R	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1219802418 CA362217206	26	D>N		No	ClinGen gnomAD
CA362217198 rs1375362476	27	A>P		No	ClinGen gnomAD
rs1339777818 CA362217189	28	T>I		No	ClinGen gnomAD
rs1275687966 CA362217182	29	N>S		No	ClinGen gnomAD
CA362217173 rs1401344162	30	P>L		No	ClinGen gnomAD
rs138219439 CA132537095	31	P>S		No	ClinGen ESP TOPMed gnomAD
rs1301949879 CA362217162	32	E>D		No	ClinGen gnomAD
rs766852840 CA3564110	32	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1464851915 CA362217133	36	D>E		No	ClinGen gnomAD
CA362217125 rs1361317042	38	S>R		No	ClinGen gnomAD
CA3564108 rs147001479	38	S>R		No	ClinGen ESP ExAC gnomAD
rs1196261289 CA362217108	40	Q>R		No	ClinGen gnomAD
rs769870162 CA3564107	44	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3564106 rs148833559	44	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA132537092 rs929674037	51	A>T		No	ClinGen Ensembl
CA3564088 rs199859079	51	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs62636573 CA132536901	52	E>G		No	ClinGen gnomAD
rs1237426438 CA362217001	54	Q>H		No	ClinGen TOPMed
CA362216994 rs1264278133	55	H>L		No	ClinGen gnomAD
CA3564084 rs777050582	57	L>F		No	ClinGen ExAC gnomAD
CA362216967 rs1313048060	59	N>S		No	ClinGen TOPMed gnomAD
CA3564080 rs770708060	60	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs770708060 CA3564081	60	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1448094852 CA362216947	62	D>E		No	ClinGen gnomAD
CA3564078 rs773130884	62	D>N		No	ClinGen ExAC
rs370833041 CA3564076	67	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA362216904 rs1459533013	69	E>K		No	ClinGen gnomAD
rs376762243 CA3564073	72	E>K		No	ClinGen ESP ExAC gnomAD
CA362216882 rs376762243	72	E>Q		No	ClinGen ESP ExAC gnomAD
rs1037532480 CA132536898	73	N>D		No	ClinGen Ensembl
CA3564072 rs780297853	73	N>S		No	ClinGen ExAC gnomAD
CA3564070 rs750959444	79	R>Q		No	ClinGen ExAC gnomAD
COSM1065906 rs758725089 CA3564071	79	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs757329205 CA3564068	82	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs988026115 CA132536895	83	G>R		No	ClinGen TOPMed
rs146441603 CA3564065	86	M>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764227728 CA3564066	86	M>K		No	ClinGen ExAC gnomAD
rs766088063 CA362216779	87	T>I		No	ClinGen ExAC gnomAD
rs766088063 CA3564063	87	T>N		No	ClinGen ExAC gnomAD
CA3564064 rs775794210	87	T>P		No	ClinGen ExAC gnomAD
CA3564062 rs762800064	89	L>V		No	ClinGen ExAC gnomAD
CA3564061 rs773075267	90	H>N		No	ClinGen ExAC TOPMed gnomAD
CA3564060 rs748039896	91	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1391631792 CA362216750	92	A>T		No	ClinGen gnomAD
CA362216722 rs1313072372	96	D>Y		No	ClinGen TOPMed
rs1467461601 CA362219913	101	S>L		No	ClinGen gnomAD
CA362219901 rs1581139786	103	I>V		No	ClinGen Ensembl
rs1429947690 CA362219886	105	D>H		No	ClinGen TOPMed gnomAD
rs769283117 CA3564044	106	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs761755527 CA3564041	110	K>E		No	ClinGen ExAC gnomAD
CA3564039 rs768222549	112	H>N		No	ClinGen ExAC gnomAD
CA132536573 rs982687618	113	A>T		No	ClinGen TOPMed
CA3564037 rs775055321	114	L>P		No	ClinGen ExAC gnomAD
rs193154184 CA132536572	115	R>Q		No	ClinGen 1000Genomes TOPMed gnomAD
rs779357671 CA3564034	116	H>N		No	ClinGen ExAC gnomAD
rs925905197 CA132536571 COSM1436067	119	G>S	large_intestine Variant assessed as Somatic; 4.629e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA362219783 rs1415984886	121	I>L		No	ClinGen TOPMed gnomAD
rs1415984886 CA362219782	121	I>V		No	ClinGen TOPMed gnomAD
rs749813011 CA3564032	122	S>R		No	ClinGen ExAC gnomAD
rs146639722 CA3564031	123	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs369005616 CA3564029	126	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1472235601 CA362219729	129	R>K		No	ClinGen gnomAD
CA362219710 TCGA novel rs1190020700	131	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen gnomAD
rs765021377 CA132536570	134	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA3564026 rs375274614	134	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1197365745 CA362219689	135	L>M		No	ClinGen TOPMed gnomAD
rs1197365745 CA362219688	135	L>V		No	ClinGen TOPMed gnomAD
rs1320642544 CA362219682	136	Q>E		No	ClinGen gnomAD
rs753833263 CA3564023	137	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs753833263 CA3564024	137	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1273720400 CA362219673	137	R>W		No	ClinGen gnomAD
rs1458183063 CA362219654	140	Y>H		No	ClinGen TOPMed
rs1286225970 CA362219646	141	L>V		No	ClinGen gnomAD
rs199713538 CA3564022	142	K>T		No	ClinGen 1000Genomes ExAC gnomAD
rs372362093 CA3564021 COSM1310974	144	D>N	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA3564019 rs372250146	147	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA362219602 rs1328886992	147	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1411138299 CA362219596	148	A>V		No	ClinGen gnomAD
CA362219576 rs1164702088	151	E>G		No	ClinGen gnomAD
CA3564016 rs144381958 COSM3723728	154	R>Q	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA3564017 rs148514784	154	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA3564014 rs778470092	155	V>L		No	ClinGen ExAC TOPMed gnomAD
CA3564013 rs770457435	157	V>M		No	ClinGen ExAC gnomAD
rs576293542 CA132536566	158	E>D		No	ClinGen 1000Genomes gnomAD
CA132536565 rs1005423667	159	M>I		No	ClinGen TOPMed
CA3564011 rs781348919	160	I>F		No	ClinGen ExAC gnomAD
rs556400982 CA3564009	161	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA3564010 rs754950313 COSM3661715	161	H>Y	liver [Cosmic]	No	ClinGen cosmic curated ExAC
CA3564008 rs200661657	162	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs753601207	168	H>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA132536561 rs753601207 CA3564006	168	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA3564005 rs143646937	169	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA362219445 rs1342125700	170	P>T		No	ClinGen TOPMed
rs539321647 CA132536031 CA362219431	172	V>L		No	ClinGen TOPMed gnomAD
rs539321647 CA132536030	172	V>M		No	ClinGen TOPMed gnomAD
rs752743454 CA3563963	175	V>A		No	ClinGen ExAC gnomAD
CA362219413 rs1382451005	175	V>M		No	ClinGen gnomAD
CA362219403 rs1220969720	176	N>T		No	ClinGen TOPMed
rs1284525350 CA362219395	177	L>F		No	ClinGen TOPMed
CA3563961 rs754563940	185	V>M		No	ClinGen ExAC gnomAD
CA3563960 rs751080486	188	A>T		No	ClinGen ExAC gnomAD
rs1581138088 CA362219313	190	T>P		No	ClinGen Ensembl
rs1275905684 CA362219299	192	S>G		No	ClinGen gnomAD
rs570098824 CA3563958	193	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs570098824 CA3563957	193	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765703541 CA3563956	195	V>F		No	ClinGen ExAC gnomAD
CA362219280 rs765703541	195	V>I		No	ClinGen ExAC gnomAD
CA362219230 rs1446339196	201	W>*		No	ClinGen gnomAD
rs1581138072 CA362219233	201	W>G		No	ClinGen Ensembl
CA132536026 rs886378430	204	L>M		No	ClinGen Ensembl
rs1177865235 CA362219177	209	S>N		No	ClinGen gnomAD
rs1177865235 CA362219176	209	S>T		No	ClinGen gnomAD
rs1377942293 CA362219161	211	C>Y		No	ClinGen TOPMed
rs1581138054 CA362219155	212	T>P		No	ClinGen Ensembl
rs1554096960 CA362219145 COSM1292093	213	S>L	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated Ensembl
CA362219143 rs1421490944	214	A>P		No	ClinGen gnomAD
CA362219127 rs1429290821	216	Q>R		No	ClinGen gnomAD
CA3563952 rs370205303	217	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1482180710 CA362219112	218	P>L		No	ClinGen gnomAD
CA3563951 rs150805735	218	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA362219101 rs894940812	220	T>K		No	ClinGen gnomAD
rs894940812 CA132536024	220	T>M		No	ClinGen gnomAD
CA132536023 rs775172802 COSM4155621	221	A>V	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA3563948 rs779102299	222	P>S		No	ClinGen ExAC gnomAD
TCGA novel	223	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362219078 rs1311634104	224	E>D		No	ClinGen gnomAD
CA3563945 rs781227018	224	E>K		No	ClinGen ExAC TOPMed
rs760095741	224	E>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	224	E>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3563943 COSM247627 rs754896450	225	R>C	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM287168 rs768636098 CA3563942	225	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA3563937 rs367702518	228	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA362219054 rs1299923955	228	Q>L		No	ClinGen gnomAD
CA362219039 rs530241742	230	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA132536021 rs928692071	231	R>G		No	ClinGen gnomAD
rs754187067 CA3563935	232	T>A		No	ClinGen ExAC gnomAD
CA3563932 rs775909005	234	L>F		No	ClinGen ExAC TOPMed gnomAD
CA3563931 rs772205469	236	R>K		No	ClinGen ExAC gnomAD
CA362219002 rs1480708858 COSM1065903	237	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs774678758 CA3563929	238	H>Q		No	ClinGen ExAC gnomAD
CA3563926 rs375944211 CA3563927	240	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1316109716 CA362218970	241	E>D		No	ClinGen TOPMed gnomAD
COSM1696765 CA362218977 rs1463268602	241	E>K	skin [Cosmic]	No	ClinGen cosmic curated TOPMed
rs561100501 CA3563925	242	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA362218954 rs1375288846	244	H>R		No	ClinGen gnomAD
rs1420735451 CA362218956	244	H>Y		No	ClinGen TOPMed gnomAD
rs200270109 CA362218948	245	H>P		No	ClinGen 1000Genomes ExAC gnomAD
rs780130118 CA3563923	245	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs200270109 CA3563924	245	H>R		No	ClinGen 1000Genomes ExAC gnomAD
rs913493869 CA132536020	245	H>Y		No	ClinGen TOPMed gnomAD
CA362218933 rs1244693225	248	E>Q		No	ClinGen TOPMed
CA362218920 rs1285216743	249	P>L		No	ClinGen TOPMed
CA3563922 rs758032028	250	S>N		No	ClinGen ExAC gnomAD
CA362218919 rs1358880025	250	S>R		No	ClinGen TOPMed
CA362218913 rs1366449937	250	S>R		No	ClinGen gnomAD
CA132536018 rs771592824	251	S>N		No	ClinGen Ensembl
CA3563921 rs749923080	253	E>K		No	ClinGen ExAC gnomAD
TCGA novel	256	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs889171811 CA132536016	256	R>Q		No	ClinGen TOPMed gnomAD
CA3563919 rs148204564	257	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3563920 rs148204564	257	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371405184 CA3563918	262	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA362218835 rs1207577111	263	G>A		No	ClinGen gnomAD
rs1265988959 CA362218838	263	G>R		No	ClinGen gnomAD
rs1490727027 CA362218826	264	S>R		No	ClinGen gnomAD
rs764369553 CA3563917	266	S>G		No	ClinGen ExAC gnomAD
CA3563916 rs761021786	267	H>N		No	ClinGen ExAC gnomAD
rs545526580 CA132536015	267	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3563914 rs377333538	269	N>D		No	ClinGen ESP ExAC gnomAD
CA362218791 rs775023312	269	N>K		No	ClinGen ExAC TOPMed gnomAD
COSM1436063 rs373237346 CA3563912	270	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1406875071 CA362218783	271	H>Y		No	ClinGen gnomAD
CA362218777 rs1168822405	272	A>T		No	ClinGen TOPMed
rs1297886403 CA362218770	273	R>*		No	ClinGen gnomAD
rs371249080 CA3563909	273	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs768635319 CA3563908	274	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1454205875 CA362218761	275	R>G		No	ClinGen TOPMed gnomAD
rs775610079 CA3563906	276	V>D		No	ClinGen ExAC TOPMed gnomAD
rs137947483 CA3563907	276	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs778297660 CA3563904	278	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs778297660 CA3563903	278	G>V		No	ClinGen ExAC TOPMed gnomAD
rs756719350 CA3563902	279	L>F		No	ClinGen ExAC gnomAD
CA132536012 rs267600554	280	G>E		No	ClinGen Ensembl
CA362218728 rs1444926070	281	A>D		No	ClinGen gnomAD
CA362218726 rs1444926070	281	A>V		No	ClinGen gnomAD
rs886074143 CA132536011	282	Q>R		No	ClinGen Ensembl
rs1206110908 CA362218715	283	G>E		No	ClinGen gnomAD
rs756515690 CA3563899	284	P>L		No	ClinGen ExAC gnomAD
CA3563896 CA3563897 rs368820616	286	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1277653641 COSM1266916 CA362218681	289	E>K	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA3563894 COSM1672132 rs766439549	290	W>*	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA362218665 rs1256709561	291	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs191497817 CA3563893	292	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1319999350 CA362218657	292	D>N		No	ClinGen gnomAD
CA3563891 COSM1642680 rs148037199	293	E>K	stomach [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs762087967 CA3563890	294	Q>*		No	ClinGen ExAC gnomAD
rs775448844 CA3563889 COSM208100	301	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA362218589 rs1262194263	302	R>G		No	ClinGen TOPMed

No associated diseases with O76061

1 regional properties for O76061

Type	Name	Position	InterPro Accession
domain	RecF/RecN/SMC, N-terminal	4 - 502	IPR003395

Functions

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.

4 GO annotations of molecular function

Name	Definition
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
heme binding	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
hormone activity	The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
protein homodimerization activity	Binding to an identical protein to form a homodimer.

12 GO annotations of biological process

Name	Definition
cellular calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
cellular response to hypoxia	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
decidualization	The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.
embryo implantation	Attachment of the blastocyst to the uterine lining.
endoplasmic reticulum unfolded protein response	The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of multicellular organism growth	Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.
regulation of hormone biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.
regulation of store-operated calcium entry	Any process that modulates the frequency, rate or extent of store-operated calcium entry.
response to oxidative stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
response to peptide hormone	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
response to vitamin D	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MCAERLGQFM	TLALVLATFD	PARGTDATNP	PEGPQDRSSQ	QKGRLSLQNT	AEIQHCLVNA
70	80	90	100	110	120
GDVGCGVFEC	FENNSCEIRG	LHGICMTFLH	NAGKFDAQGK	SFIKDALKCK	AHALRHRFGC
130	140	150	160	170	180
ISRKCPAIRE	MVSQLQRECY	LKHDLCAAAQ	ENTRVIVEMI	HFKDLLLHEP	YVDLVNLLLT
190	200	210	220	230	240
CGEEVKEAIT	HSVQVQCEQN	WGSLCSILSF	CTSAIQKPPT	APPERQPQVD	RTKLSRAHHG
250	260	270	280	290	300
EAGHHLPEPS	SRETGRGAKG	ERGSKSHPNA	HARGRVGGLG	AQGPSGSSEW	EDEQSEYSDI

RR