O75840
PR
Gene name |
KLF7 |
Protein name |
Krueppel-like factor 7 |
Names |
Ubiquitous krueppel-like factor |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:8609 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O75840
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O75840-F1 | Predicted | AlphaFoldDB |
169 variants for O75840
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA350157588 RCV001267563 RCV003128382 COSM1641800 RCV003147605 VAR_081574 rs1276619385 RCV001880150 |
137 | T>M | stomach Inborn genetic diseases KLF7-related neurodevelopmental disorder found in two patients with developmental delay/intellectual disability, neuromuscular and psychiatric symptoms; unknown pathological significance [Cosmic, ClinVar, UniProt] | Yes |
ClinGen cosmic curated ClinVar UniProt dbSNP gnomAD |
| TCGA novel | 3 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs780081096 CA2075960 |
11 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA350157069 rs1314135549 |
15 | L>V | No |
ClinGen TOPMed |
|
|
CA2075957 rs778107793 |
21 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs200395387 CA64707208 |
22 | F>L | No |
ClinGen 1000Genomes |
|
|
rs1265308224 CA350156928 |
23 | S>L | No |
ClinGen gnomAD |
|
|
rs1283605397 CA350158197 |
45 | T>M | No |
ClinGen gnomAD |
|
|
COSM1641801 rs746774122 CA2075916 |
48 | R>Q | stomach [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA350158167 rs1382181220 |
50 | I>N | No |
ClinGen TOPMed |
|
| TCGA novel | 51 | S>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs779150059 CA2075915 |
55 | G>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs756121319 CA2075911 |
62 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1177496928 CA350158060 |
63 | H>N | No |
ClinGen gnomAD |
|
|
CA350158058 rs1481282809 |
63 | H>P | No |
ClinGen gnomAD |
|
|
rs1043844098 CA64683291 |
64 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1232482014 CA350158051 |
64 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs996307464 CA64683283 |
65 | S>F | No |
ClinGen TOPMed gnomAD |
|
|
rs781689074 CA2075909 |
67 | P>A | No |
ClinGen ExAC gnomAD |
|
|
CA350158034 rs1196134985 |
67 | P>R | No |
ClinGen gnomAD |
|
| rs1559141567 | 68 | P>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs754250188 CA2075906 |
68 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA2075907 rs751930376 |
68 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350158031 rs751930376 |
68 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350158025 rs1253472971 |
69 | C>Y | No |
ClinGen TOPMed |
|
|
CA350158017 rs1233005901 |
70 | I>T | No |
ClinGen gnomAD |
|
|
rs528030299 CA2075904 |
70 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA350158003 rs1334032145 |
72 | E>A | No |
ClinGen gnomAD |
|
|
CA2075903 rs764850875 |
74 | F>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs368678068 COSM3787963 CA2075902 |
75 | R>C | pancreas [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA2075901 rs547340911 |
75 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs149669336 CA2075900 |
76 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs760440437 CA2075899 |
76 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 77 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA350157974 rs1171719090 |
77 | L>V | No |
ClinGen gnomAD |
|
|
CA2075898 rs376571122 |
78 | D>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2075896 rs749518114 |
79 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs974286471 CA64683156 |
79 | P>L | No |
ClinGen Ensembl |
|
|
CA350157956 rs1317883622 |
80 | L>V | No |
ClinGen gnomAD |
|
|
rs1277485773 CA350157941 |
83 | P>S | No |
ClinGen gnomAD |
|
|
rs200852970 CA2075891 |
84 | V>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1374390582 CA350157924 |
85 | E>D | No |
ClinGen TOPMed |
|
| TCGA novel | 87 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1376851772 CA350157906 |
88 | I>T | No |
ClinGen gnomAD |
|
|
rs1574503992 CA350157909 |
88 | I>V | No |
ClinGen Ensembl |
|
|
CA350157899 rs1315759997 |
89 | C>Y | No |
ClinGen gnomAD |
|
|
CA2075887 rs752417303 |
93 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA350157864 rs1316418213 |
94 | A>S | No |
ClinGen TOPMed |
|
|
rs373445474 CA2075885 |
97 | I>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs766288622 CA2075883 |
97 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs373445474 CA2075884 |
97 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350157830 rs1418973728 |
99 | L>R | No |
ClinGen gnomAD |
|
|
CA2075881 rs773069957 |
101 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350157822 rs369397059 |
101 | R>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2075880 rs369397059 |
101 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 102 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1337724135 CA350157806 |
103 | K>N | No |
ClinGen gnomAD |
|
|
rs1488804013 CA350157777 |
108 | T>A | No |
ClinGen gnomAD |
|
|
rs1488804013 CA350157778 |
108 | T>P | No |
ClinGen gnomAD |
|
|
rs955958552 CA64683008 |
108 | T>S | No |
ClinGen Ensembl |
|
|
rs1214936039 CA350157758 |
111 | S>G | No |
ClinGen gnomAD |
|
|
rs745993873 CA2075876 |
114 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs745993873 CA350157734 |
114 | P>Q | No |
ClinGen ExAC gnomAD |
|
|
CA2075874 rs372341499 |
115 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2075873 rs747529783 |
116 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA2075872 rs778373924 |
116 | S>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 117 | S>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1399548220 CA350157710 |
118 | S>F | No |
ClinGen TOPMed gnomAD |
|
|
rs917165849 CA350157704 |
120 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
rs917165849 CA64682901 |
120 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA350157684 rs1166902340 |
122 | Y>C | No |
ClinGen gnomAD |
|
|
rs778475315 CA2075869 |
123 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1168024531 CA350157673 |
124 | A>D | No |
ClinGen gnomAD |
|
|
rs536720710 CA2075867 |
125 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs375295716 CA2075866 |
126 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1247784362 CA350157648 |
128 | A>T | No |
ClinGen gnomAD |
|
|
rs755564834 CA2075865 |
130 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs200699335 CA64682842 CA350157625 |
131 | N>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350157627 rs1289183404 |
131 | N>S | No |
ClinGen gnomAD |
|
|
CA350157623 rs1372858612 |
132 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1295181536 CA350157618 |
133 | V>M | No |
ClinGen TOPMed |
|
|
rs1177221117 CA350157608 |
134 | T>N | No |
ClinGen gnomAD |
|
|
CA350157609 rs1177221117 |
134 | T>S | No |
ClinGen gnomAD |
|
|
rs1457593595 CA350157597 |
136 | L>S | No |
ClinGen gnomAD |
|
|
CA2075861 rs774118640 |
138 | P>L | No |
ClinGen ExAC |
|
|
CA350157577 rs1244054104 |
139 | P>L | No |
ClinGen gnomAD |
|
| VAR_081575 | 139 | P>S | found in a patient with developmental delay/intellectual disability, neuromuscular and psychiatric symptoms; unknown pathological significance [UniProt] | No | UniProt |
|
rs1231413667 COSM1738640 CA350157571 |
140 | S>L | Variant assessed as Somatic; impact. central_nervous_system haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
| TCGA novel | 140 | S>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs771063540 CA2075857 |
146 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs747043061 CA2075856 |
146 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs747043061 CA350157533 |
146 | R>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA2075855 rs749629247 |
147 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs866824549 CA64682792 |
147 | H>Y | No |
ClinGen Ensembl |
|
|
rs772681371 CA2075854 |
149 | V>F | No |
ClinGen ExAC gnomAD |
|
|
rs772681371 CA350157521 |
149 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA2075852 rs201827394 |
151 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755234442 CA2075851 |
152 | S>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350157499 rs1487760253 |
152 | S>L | No |
ClinGen gnomAD |
|
|
rs1246647197 CA350157484 |
155 | L>I | No |
ClinGen gnomAD |
|
|
rs1459193946 CA350157473 |
156 | S>F | No |
ClinGen TOPMed gnomAD |
|
|
CA350157462 rs1370243755 |
158 | V>G | No |
ClinGen TOPMed |
|
|
rs749905619 CA2075847 |
158 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 160 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs767492398 CA2075846 |
161 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1337096454 CA350157442 |
162 | V>M | No |
ClinGen gnomAD |
|
|
CA64682717 rs567779117 |
163 | T>M | No |
ClinGen 1000Genomes gnomAD |
|
|
rs2077410023 RCV001091187 |
163 | T>P | No |
ClinVar dbSNP |
|
|
rs996297385 CA64682673 |
168 | A>S | No |
ClinGen TOPMed |
|
|
rs996297385 CA64682703 |
168 | A>T | No |
ClinGen TOPMed |
|
|
rs1216155243 CA350157395 |
169 | K>N | No |
ClinGen TOPMed |
|
|
CA2075840 rs766476942 |
171 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs367917697 CA2075839 |
172 | A>V | No |
ClinGen ESP ExAC gnomAD |
|
|
rs941231757 CA64682665 |
173 | L>V | No |
ClinGen Ensembl |
|
|
rs1178606332 CA350157369 |
174 | S>G | No |
ClinGen gnomAD |
|
|
CA64682659 rs146378446 |
176 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2075836 CA64682650 rs146378446 |
176 | V>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1574502749 CA350157341 |
178 | V>G | No |
ClinGen Ensembl |
|
|
CA2075835 rs550809782 |
178 | V>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA2075834 rs769088487 |
181 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2075832 rs769414937 |
182 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2075831 rs769414937 |
182 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA350157294 rs1454926575 |
185 | A>T | No |
ClinGen TOPMed |
|
|
CA2075828 rs756697453 |
188 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2075826 rs376354914 |
189 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs149567887 CA2075824 |
191 | A>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs149567887 CA2075823 |
191 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2075821 rs750610237 |
192 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs767721730 CA2075820 |
193 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs199543928 CA2075818 |
194 | V>I | Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA2075817 rs769015031 |
195 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA2075816 rs150163496 |
197 | G>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2075814 rs770075680 |
199 | S>I | No |
ClinGen ExAC gnomAD |
|
|
rs138111979 CA64682553 |
200 | D>G | No |
ClinGen ESP |
|
|
rs780771483 CA64682558 |
200 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1015509 rs780771483 CA2075812 |
200 | D>N | Variant assessed as Somatic; 0.0 impact. pancreas endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA350157131 rs1424539141 |
201 | S>G | No |
ClinGen gnomAD |
|
|
rs746466547 CA350157102 |
203 | Q>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2075810 rs746466547 |
203 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2075806 rs778858728 |
207 | G>W | No |
ClinGen ExAC gnomAD |
|
|
rs750699704 CA350157054 |
208 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750699704 CA2075804 |
208 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750699704 CA2075805 |
208 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1247885776 CA350157004 |
212 | P>R | No |
ClinGen TOPMed |
|
|
COSM3838424 CA2075802 rs761995114 |
213 | E>K | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
| TCGA novel | 214 | N>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA64682499 rs1018436671 |
220 | R>C | No |
ClinGen gnomAD |
|
|
rs770163646 CA2075797 |
227 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
CA2075798 COSM1404872 rs371003779 |
227 | R>W | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1158631896 CA350156746 |
233 | S>N | No |
ClinGen gnomAD |
|
| TCGA novel | 233 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs776302492 CA2075795 |
238 | A>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 243 | H>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1574422898 CA350156454 |
250 | K>R | No |
ClinGen Ensembl |
|
|
rs941470359 CA64660681 |
252 | S>L | No |
ClinGen Ensembl |
|
| TCGA novel | 256 | C>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs778013943 CA2075766 |
259 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs927327960 COSM209744 CA64660675 |
259 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
VAR_081576 rs1057518995 CA16043610 |
264 | D>N | found in a patient with developmental delay/intellectual disability, neuromuscular and psychiatric symptoms; unknown pathological significance [UniProt] | No |
ClinGen UniProt Ensembl dbSNP |
|
rs752748085 CA2075764 |
267 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA64660657 rs200629216 |
269 | H>R | No |
ClinGen 1000Genomes |
|
| TCGA novel | 275 | G>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA64638976 rs34762693 |
291 | S>A | No |
ClinGen Ensembl |
|
|
rs1456009961 CA350156580 |
294 | L>F | No |
ClinGen gnomAD |
|
|
CA350156564 rs1311979125 |
296 | L>V | No |
ClinGen gnomAD |
|
|
rs1259658080 CA350156548 |
298 | M>L | No |
ClinGen TOPMed |
|
|
rs772264714 CA2075747 |
298 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350156533 rs1156837098 |
299 | K>N | No |
ClinGen gnomAD |
|
|
CA64638929 rs879248332 |
303 | I>L | No |
ClinGen gnomAD |
No associated diseases with O75840
3 regional properties for O75840
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger C2H2-type | 219 - 248 | IPR013087-1 |
| domain | Zinc finger C2H2-type | 249 - 278 | IPR013087-2 |
| domain | Zinc finger C2H2-type | 279 - 302 | IPR013087-3 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| zinc ion binding | Binding to a zinc ion (Zn). |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| axonogenesis | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. |
| dendrite morphogenesis | The process in which the anatomical structures of a dendrite are generated and organized. |
| glucose homeostasis | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. |
| negative regulation of adipose tissue development | Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. |
| negative regulation of insulin secretion involved in cellular response to glucose stimulus | Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of epidermal cell differentiation | Any process that modulates the frequency, rate or extent of epidermal cell differentiation. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
177 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q08DS3 | OSR1 | Protein odd-skipped-related 1 | Bos taurus (Bovine) | PR |
| Q2VWH6 | FEZF2 | Fez family zinc finger protein 2 | Bos taurus (Bovine) | PR |
| A6QNZ0 | ZSCAN26 | Zinc finger and SCAN domain-containing protein 26 | Bos taurus (Bovine) | PR |
| A7MBI1 | ZFP69 | Zinc finger protein 69 homolog | Bos taurus (Bovine) | PR |
| Q08705 | CTCF | Transcriptional repressor CTCF | Gallus gallus (Chicken) | PR |
| O42409 | GFI1B | Zinc finger protein Gfi-1b | Gallus gallus (Chicken) | PR |
| A2T6W2 | ZNF449 | Zinc finger protein 449 | Pan troglodytes (Chimpanzee) | PR |
| Q9U405 | grau | Transcription factor grauzone | Drosophila melanogaster (Fruit fly) | PR |
| Q7K0S9 | sug | Zinc finger protein GLIS2 homolog | Drosophila melanogaster (Fruit fly) | PR |
| P20385 | Cf2 | Chorion transcription factor Cf2 | Drosophila melanogaster (Fruit fly) | PR |
| Q86P48 | ATbp | AT-rich binding protein | Drosophila melanogaster (Fruit fly) | PR |
| P28698 | MZF1 | Myeloid zinc finger 1 | Homo sapiens (Human) | PR |
| Q9NTW7 | ZFP64 | Zinc finger protein 64 | Homo sapiens (Human) | PR |
| O14978 | ZNF263 | Zinc finger protein 263 | Homo sapiens (Human) | PR |
| O60304 | ZNF500 | Zinc finger protein 500 | Homo sapiens (Human) | PR |
| P08151 | GLI1 | Zinc finger protein GLI1 | Homo sapiens (Human) | PR |
| Q9UFB7 | ZBTB47 | Zinc finger and BTB domain-containing protein 47 | Homo sapiens (Human) | PR |
| Q9UNY5 | ZNF232 | Zinc finger protein 232 | Homo sapiens (Human) | PR |
| Q96SZ4 | ZSCAN10 | Zinc finger and SCAN domain-containing protein 10 | Homo sapiens (Human) | PR |
| P17028 | ZNF24 | Zinc finger protein 24 | Homo sapiens (Human) | PR |
| P25490 | YY1 | Transcriptional repressor protein YY1 | Homo sapiens (Human) | SS |
| O43296 | ZNF264 | Zinc finger protein 264 | Homo sapiens (Human) | PR |
| P49711 | CTCF | Transcriptional repressor CTCF | Homo sapiens (Human) | PR |
| Q9NQX1 | PRDM5 | PR domain zinc finger protein 5 | Homo sapiens (Human) | PR |
| Q9HBE1 | PATZ1 | POZ-, AT hook-, and zinc finger-containing protein 1 | Homo sapiens (Human) | PR |
| Q8TAX0 | OSR1 | Protein odd-skipped-related 1 | Homo sapiens (Human) | PR |
| Q9UL58 | ZNF215 | Zinc finger protein 215 | Homo sapiens (Human) | PR |
| Q8TBJ5 | FEZF2 | Fez family zinc finger protein 2 | Homo sapiens (Human) | PR |
| Q96SR6 | ZNF382 | Zinc finger protein 382 | Homo sapiens (Human) | PR |
| Q96IT1 | ZNF496 | Zinc finger protein 496 | Homo sapiens (Human) | PR |
| Q96N95 | ZNF396 | Zinc finger protein 396 | Homo sapiens (Human) | PR |
| Q9ULJ3 | ZBTB21 | Zinc finger and BTB domain-containing protein 21 | Homo sapiens (Human) | PR |
| Q9H9D4 | ZNF408 | Zinc finger protein 408 | Homo sapiens (Human) | PR |
| Q13127 | REST | RE1-silencing transcription factor | Homo sapiens (Human) | PR |
| Q8IZM8 | ZNF654 | Zinc finger protein 654 | Homo sapiens (Human) | PR |
| Q14526 | HIC1 | Hypermethylated in cancer 1 protein | Homo sapiens (Human) | PR |
| P17022 | ZNF18 | Zinc finger protein 18 | Homo sapiens (Human) | PR |
| Q86XF7 | ZNF575 | Zinc finger protein 575 | Homo sapiens (Human) | PR |
| Q8NAM6 | ZSCAN4 | Zinc finger and SCAN domain-containing protein 4 | Homo sapiens (Human) | PR |
| Q08ER8 | ZNF543 | Zinc finger protein 543 | Homo sapiens (Human) | PR |
| P17029 | ZKSCAN1 | Zinc finger protein with KRAB and SCAN domains 1 | Homo sapiens (Human) | PR |
| Q8N680 | ZBTB2 | Zinc finger and BTB domain-containing protein 2 | Homo sapiens (Human) | PR |
| O95625 | ZBTB11 | Zinc finger and BTB domain-containing protein 11 | Homo sapiens (Human) | PR |
| Q9NPC7 | MYNN | Myoneurin | Homo sapiens (Human) | PR |
| Q96BV0 | ZNF775 | Zinc finger protein 775 | Homo sapiens (Human) | PR |
| Q8NF99 | ZNF397 | Zinc finger protein 397 | Homo sapiens (Human) | PR |
| Q63HK3 | ZKSCAN2 | Zinc finger protein with KRAB and SCAN domains 2 | Homo sapiens (Human) | PR |
| Q5FWF6 | ZNF789 | Zinc finger protein 789 | Homo sapiens (Human) | PR |
| Q15776 | ZKSCAN8 | Zinc finger protein with KRAB and SCAN domains 8 | Homo sapiens (Human) | PR |
| Q53GI3 | ZNF394 | Zinc finger protein 394 | Homo sapiens (Human) | PR |
| O95125 | ZNF202 | Zinc finger protein 202 | Homo sapiens (Human) | PR |
| Q05516 | ZBTB16 | Zinc finger and BTB domain-containing protein 16 | Homo sapiens (Human) | PR |
| Q9H116 | GZF1 | GDNF-inducible zinc finger protein 1 | Homo sapiens (Human) | PR |
| Q8N0Y2 | ZNF444 | Zinc finger protein 444 | Homo sapiens (Human) | PR |
| Q6P9G9 | ZNF449 | Zinc finger protein 449 | Homo sapiens (Human) | PR |
| Q8IW36 | ZNF695 | Zinc finger protein 695 | Homo sapiens (Human) | PR |
| Q5VTD9 | GFI1B | Zinc finger protein Gfi-1b | Homo sapiens (Human) | PR |
| Q6PG37 | ZNF790 | Zinc finger protein 790 | Homo sapiens (Human) | PR |
| Q9NQV6 | PRDM10 | PR domain zinc finger protein 10 | Homo sapiens (Human) | PR |
| Q9Y2D9 | ZNF652 | Zinc finger protein 652 | Homo sapiens (Human) | PR |
| Q5TC79 | ZBTB37 | Zinc finger and BTB domain-containing protein 37 | Homo sapiens (Human) | PR |
| Q9Y4E5 | ZNF451 | E3 SUMO-protein ligase ZNF451 | Homo sapiens (Human) | PR |
| Q8ND82 | ZNF280C | Zinc finger protein 280C | Homo sapiens (Human) | PR |
| Q49AA0 | ZFP69 | Zinc finger protein 69 homolog | Homo sapiens (Human) | PR |
| O43298 | ZBTB43 | Zinc finger and BTB domain-containing protein 43 | Homo sapiens (Human) | PR |
| Q9Y330 | ZBTB12 | Zinc finger and BTB domain-containing protein 12 | Homo sapiens (Human) | PR |
| Q13105 | ZBTB17 | Zinc finger and BTB domain-containing protein 17 | Homo sapiens (Human) | PR |
| P51508 | ZNF81 | Zinc finger protein 81 | Homo sapiens (Human) | PR |
| Q5JNZ3 | ZNF311 | Zinc finger protein 311 | Homo sapiens (Human) | PR |
| Q9BRR0 | ZKSCAN3 | Zinc finger protein with KRAB and SCAN domains 3 | Homo sapiens (Human) | PR |
| Q969J2 | ZKSCAN4 | Zinc finger protein with KRAB and SCAN domains 4 | Homo sapiens (Human) | PR |
| P49910 | ZNF165 | Zinc finger protein 165 | Homo sapiens (Human) | PR |
| P10074 | ZBTB48 | Telomere zinc finger-associated protein | Homo sapiens (Human) | PR |
| P17010 | ZFX | Zinc finger X-chromosomal protein | Homo sapiens (Human) | PR |
| Q9H5H4 | ZNF768 | Zinc finger protein 768 | Homo sapiens (Human) | PR |
| Q6NSZ9 | ZSCAN25 | Zinc finger and SCAN domain-containing protein 25 | Homo sapiens (Human) | PR |
| Q9Y2L8 | ZKSCAN5 | Zinc finger protein with KRAB and SCAN domains 5 | Homo sapiens (Human) | PR |
| Q86UZ6 | ZBTB46 | Zinc finger and BTB domain-containing protein 46 | Homo sapiens (Human) | PR |
| Q9NX65 | ZSCAN32 | Zinc finger and SCAN domain-containing protein 32 | Homo sapiens (Human) | PR |
| O14771 | ZNF213 | Zinc finger protein 213 | Homo sapiens (Human) | PR |
| Q8IWY8 | ZSCAN29 | Zinc finger and SCAN domain-containing protein 29 | Homo sapiens (Human) | PR |
| Q8NCP5 | ZBTB44 | Zinc finger and BTB domain-containing protein 44 | Homo sapiens (Human) | PR |
| P41182 | BCL6 | B-cell lymphoma 6 protein | Homo sapiens (Human) | PR |
| Q9NQX0 | PRDM6 | Putative histone-lysine N-methyltransferase PRDM6 | Homo sapiens (Human) | PR |
| Q9BU19 | ZNF692 | Zinc finger protein 692 | Homo sapiens (Human) | PR |
| Q08AG5 | ZNF844 | Zinc finger protein 844 | Homo sapiens (Human) | PR |
| Q6R2W3 | ZBED9 | SCAN domain-containing protein 3 | Homo sapiens (Human) | PR |
| P98182 | ZNF200 | Zinc finger protein 200 | Homo sapiens (Human) | PR |
| Q9UK11 | ZNF223 | Zinc finger protein 223 | Homo sapiens (Human) | PR |
| O15156 | ZBTB7B | Zinc finger and BTB domain-containing protein 7B | Homo sapiens (Human) | PR |
| Q6ZMS7 | ZNF783 | Zinc finger protein 783 | Homo sapiens (Human) | PR |
| P59923 | ZNF445 | Zinc finger protein 445 | Homo sapiens (Human) | PR |
| Q8N859 | ZNF713 | Zinc finger protein 713 | Homo sapiens (Human) | PR |
| Q8TD17 | ZNF398 | Zinc finger protein 398 | Homo sapiens (Human) | PR |
| P52739 | ZNF131 | Zinc finger protein 131 | Homo sapiens (Human) | PR |
| A6NGD5 | ZSCAN5C | Zinc finger and SCAN domain-containing protein 5C | Homo sapiens (Human) | PR |
| Q7Z398 | ZNF550 | Zinc finger protein 550 | Homo sapiens (Human) | PR |
| Q9Y2K1 | ZBTB1 | Zinc finger and BTB domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q96N20 | ZNF75A | Zinc finger protein 75A | Homo sapiens (Human) | PR |
| A6NJL1 | ZSCAN5B | Zinc finger and SCAN domain-containing protein 5B | Homo sapiens (Human) | PR |
| A1YPR0 | ZBTB7C | Zinc finger and BTB domain-containing protein 7C | Homo sapiens (Human) | PR |
| Q9NWS9 | ZNF446 | Zinc finger protein 446 | Homo sapiens (Human) | PR |
| P24278 | ZBTB25 | Zinc finger and BTB domain-containing protein 25 | Homo sapiens (Human) | PR |
| Q96N38 | ZNF714 | Zinc finger protein 714 | Homo sapiens (Human) | PR |
| Q86YH2 | ZNF280B | Zinc finger protein 280B | Homo sapiens (Human) | PR |
| Q9Y5W3 | KLF2 | Krueppel-like factor 2 | Homo sapiens (Human) | PR |
| Q06889 | EGR3 | Early growth response protein 3 | Homo sapiens (Human) | PR |
| P18146 | EGR1 | Early growth response protein 1 | Homo sapiens (Human) | PR |
| Q05215 | EGR4 | Early growth response protein 4 | Homo sapiens (Human) | PR |
| Q9Y4X4 | KLF12 | Krueppel-like factor 12 | Homo sapiens (Human) | PR |
| Q99612 | KLF6 | Krueppel-like factor 6 | Homo sapiens (Human) | PR |
| P57682 | KLF3 | Krueppel-like factor 3 | Homo sapiens (Human) | PR |
| O08584 | Klf6 | Krueppel-like factor 6 | Mus musculus (Mouse) | PR |
| Q61164 | Ctcf | Transcriptional repressor CTCF | Mus musculus (Mouse) | PR |
| Q810A1 | Znf18 | Zinc finger protein 18 | Mus musculus (Mouse) | PR |
| Q8BGS3 | Zkscan1 | Zinc finger protein with KRAB and SCAN domains 1 | Mus musculus (Mouse) | PR |
| Q00899 | Yy1 | Transcriptional repressor protein YY1 | Mus musculus (Mouse) | PR |
| P41183 | Bcl6 | B-cell lymphoma 6 protein homolog | Mus musculus (Mouse) | PR |
| Q9DAI4 | Zbtb43 | Zinc finger and BTB domain-containing protein 43 | Mus musculus (Mouse) | PR |
| O70237 | Gfi1b | Zinc finger protein Gfi-1b | Mus musculus (Mouse) | PR |
| Q99KZ6 | Znf639 | Zinc finger protein 639 | Mus musculus (Mouse) | PR |
| Q9Z1D9 | Znf394 | Zinc finger protein 394 | Mus musculus (Mouse) | PR |
| Q9CXE0 | Prdm5 | PR domain zinc finger protein 5 | Mus musculus (Mouse) | PR |
| P43300 | Egr3 | Early growth response protein 3 | Mus musculus (Mouse) | PR |
| Q9DAU9 | Znf654 | Zinc finger protein 654 | Mus musculus (Mouse) | PR |
| Q9R1Y5 | Hic1 | Hypermethylated in cancer 1 protein | Mus musculus (Mouse) | PR |
| Q8R0T2 | Znf768 | Zinc finger protein 768 | Mus musculus (Mouse) | PR |
| Q9WVG7 | Osr1 | Protein odd-skipped-related 1 | Mus musculus (Mouse) | PR |
| Q8BI73 | Znf775 | Zinc finger protein 775 | Mus musculus (Mouse) | PR |
| Q8VCZ7 | Zbtb7c | Zinc finger and BTB domain-containing protein 7C | Mus musculus (Mouse) | PR |
| Q91VN1 | Znf24 | Zinc finger protein 24 | Mus musculus (Mouse) | PR |
| Q9DB38 | Znf580 | Zinc finger protein 580 | Mus musculus (Mouse) | PR |
| A7KBS4 | Zscan4d | Zinc finger and SCAN domain containing protein 4D | Mus musculus (Mouse) | PR |
| Q91VW9 | Zkscan3 | Zinc finger protein with KRAB and SCAN domains 3 | Mus musculus (Mouse) | PR |
| P10925 | Zfy1 | Zinc finger Y-chromosomal protein 1 | Mus musculus (Mouse) | PR |
| P08046 | Egr1 | Early growth response protein 1 | Mus musculus (Mouse) | PR |
| Q3TTC2 | Yy2 | Transcription factor YY2 | Mus musculus (Mouse) | PR |
| Q3UTQ7 | Prdm10 | PR domain zinc finger protein 10 | Mus musculus (Mouse) | PR |
| Q6P3Y5 | Znf280c | Zinc finger protein 280C | Mus musculus (Mouse) | PR |
| Q9ERU3 | Znf22 | Zinc finger protein 22 | Mus musculus (Mouse) | PR |
| Q8VIG1 | Rest | RE1-silencing transcription factor | Mus musculus (Mouse) | PR |
| Q9Z1D8 | Zkscan5 | Zinc finger protein with KRAB and SCAN domains 5 | Mus musculus (Mouse) | PR |
| Q8BID6 | Zbtb46 | Zinc finger and BTB domain-containing protein 46 | Mus musculus (Mouse) | PR |
| P17012 | Zfx | Zinc finger X-chromosomal protein | Mus musculus (Mouse) | PR |
| Q9WUK6 | Zbtb18 | Zinc finger and BTB domain-containing protein 18 | Mus musculus (Mouse) | PR |
| O35738 | Klf12 | Krueppel-like factor 12 | Mus musculus (Mouse) | PR |
| B2RXC5 | Znf382 | Zinc finger protein 382 | Mus musculus (Mouse) | PR |
| O08900 | Ikzf3 | Zinc finger protein Aiolos | Mus musculus (Mouse) | PR |
| Q5DU09 | Znf652 | Zinc finger protein 652 | Mus musculus (Mouse) | PR |
| Q5RJ54 | Zscan26 | Zinc finger and SCAN domain-containing protein 26 | Mus musculus (Mouse) | PR |
| Q8BLM0 | Klf8 | Krueppel-like factor 8 | Mus musculus (Mouse) | PR |
| Q8R0A2 | Zbtb44 | Zinc finger and BTB domain-containing protein 44 | Mus musculus (Mouse) | PR |
| P20662 | Zfy2 | Zinc finger Y-chromosomal protein 2 | Mus musculus (Mouse) | PR |
| Q80VJ6 | Zscan4c | Zinc finger and SCAN domain containing protein 4C | Mus musculus (Mouse) | PR |
| Q3URS2 | Zscan4f | Zinc finger and SCAN domain containing protein 4F | Mus musculus (Mouse) | PR |
| Q60980 | Klf3 | Krueppel-like factor 3 | Mus musculus (Mouse) | PR |
| Q8K3J5 | Znf131 | Zinc finger protein 131 | Mus musculus (Mouse) | PR |
| Q99JB0 | Klf7 | Krueppel-like factor 7 | Mus musculus (Mouse) | PR |
| Q9Z2K3 | Znf394 | Zinc finger protein 394 | Rattus norvegicus (Rat) | PR |
| Q642B9 | Znf18 | Zinc finger protein 18 | Rattus norvegicus (Rat) | PR |
| B0K011 | Osr1 | Protein odd-skipped-related 1 | Rattus norvegicus (Rat) | PR |
| D3ZUU2 | Gzf1 | GDNF-inducible zinc finger protein 1 | Rattus norvegicus (Rat) | PR |
| B1WBU4 | Zbtb8a | Zinc finger and BTB domain-containing protein 8A | Rattus norvegicus (Rat) | PR |
| Q7TNK3 | Znf24 | Zinc finger protein 24 | Rattus norvegicus (Rat) | PR |
| O35819 | Klf6 | Krueppel-like factor 6 | Rattus norvegicus (Rat) | PR |
| Q9R1D1 | Ctcf | Transcriptional repressor CTCF | Rattus norvegicus (Rat) | PR |
| P43301 | Egr3 | Early growth response protein 3 | Rattus norvegicus (Rat) | PR |
| P08154 | Egr1 | Early growth response protein 1 | Rattus norvegicus (Rat) | PR |
| A0JPL0 | Znf382 | Zinc finger protein 382 | Rattus norvegicus (Rat) | PR |
| Q4KLI1 | Zkscan1 | Zinc finger protein with KRAB and SCAN domains 1 | Rattus norvegicus (Rat) | PR |
| A1L1J6 | Znf652 | Zinc finger protein 652 | Rattus norvegicus (Rat) | PR |
| Q9SHD0 | ZAT4 | Zinc finger protein ZAT4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0P4X6 | zbtb44 | Zinc finger and BTB domain-containing protein 44 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| A4II20 | egr1 | Early growth response protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6P882 | zbtb8a.2 | Zinc finger and BTB domain-containing protein 8A.2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q567C6 | znf367 | Zinc finger protein 367 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| A7Y7X5 | znf711 | Zinc finger protein 711 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDVLASYSIF | QELQLVHDTG | YFSALPSLEE | TWQQTCLELE | RYLQTEPRRI | SETFGEDLDC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLHASPPPCI | EESFRRLDPL | LLPVEAAICE | KSSAVDILLS | RDKLLSETCL | SLQPASSSLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SYTAVNQAQL | NAVTSLTPPS | SPELSRHLVK | TSQTLSAVDG | TVTLKLVAKK | AALSSVKVGG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VATAAAAVTA | AGAVKSGQSD | SDQGGLGAEA | CPENKKRVHR | CQFNGCRKVY | TKSSHLKAHQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RTHTGEKPYK | CSWEGCEWRF | ARSDELTRHY | RKHTGAKPFK | CNHCDRCFSR | SDHLALHMKR |
| HI |