AiPD: Autoinhibited Protein Database

O75663

Gene name	TIPRL
Protein name	TIP41-like protein
Names	Putative MAPK-activating protein PM10, Type 2A-interacting protein, TIP
Species	Homo sapiens (Human)
KEGG Pathway	hsa:261726
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

59-175 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

59-175 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for O75663

Entry ID	Method	Resolution	Chain	Position	Source
5D9G	X-ray	215 A	A/B	16-256	PDB
AF-O75663-F1	Predicted				AlphaFoldDB

149 variants for O75663

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1265988654 CA343081370	2	M>I		No	ClinGen gnomAD
rs1199162254 CA343081342	2	M>K		No	ClinGen TOPMed
CA31454976 rs891528712	4	H>N		No	ClinGen Ensembl
rs746172242 CA1229876	4	H>Q		No	ClinGen ExAC gnomAD
CA1229877 rs772353524	8	S>C		No	ClinGen ExAC gnomAD
CA1229878 rs775627089	8	S>N		No	ClinGen ExAC gnomAD
CA1229879 rs760815085	8	S>R		No	ClinGen ExAC gnomAD
CA343081691 rs1572426929	10	H>P		No	ClinGen Ensembl
CA343081736 rs1572426940 TCGA novel	12	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs1029481863 CA31454991	13	F>I		No	ClinGen Ensembl
rs768711827 CA343081860	14	C>F		No	ClinGen ExAC gnomAD
CA343081841 rs1465582648	14	C>G		No	ClinGen gnomAD
CA1229880 rs768711827	14	C>S		No	ClinGen ExAC gnomAD
CA343081875 rs1255865387	15	F>L		No	ClinGen TOPMed
rs1478313027 CA343081953	17	P>T		No	ClinGen gnomAD
rs776601529 CA1229881	19	K>R		No	ClinGen ExAC gnomAD
rs1459479070 CA343082097	20	L>M		No	ClinGen gnomAD
rs761839555 CA1229882	21	T>A		No	ClinGen ExAC gnomAD
rs1350124740 CA343082136	21	T>R		No	ClinGen TOPMed gnomAD
rs1379364925 CA343082235	23	S>C		No	ClinGen TOPMed
CA343082276 rs1438115101	24	K>N		No	ClinGen gnomAD
rs955676480 CA31454995	25	T>S		No	ClinGen TOPMed gnomAD
CA31455008 rs985559103	26	H>L		No	ClinGen Ensembl
rs1339646550 CA343082358	27	I>V		No	ClinGen gnomAD
rs371476972 CA31455012	31	A>T		No	ClinGen Ensembl
rs752266948 CA1229908	38	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1041169699 CA31457153	39	E>D		No	ClinGen TOPMed
rs879181819 CA31457162	41	H>R		No	ClinGen Ensembl
CA343085002 rs1160266672	41	H>Y		No	ClinGen gnomAD
CA1229910 rs765840211	42	M>K		No	ClinGen ExAC TOPMed gnomAD
rs765840211 CA343085020	42	M>T		No	ClinGen ExAC TOPMed gnomAD
CA343085014 rs1211967147	42	M>V		No	ClinGen TOPMed
CA1229911 rs750885301	44	S>A		No	ClinGen ExAC gnomAD
CA1229912 rs758814194	44	S>Y		No	ClinGen ExAC gnomAD
rs747323502 CA1229914	47	E>A		No	ClinGen ExAC gnomAD
rs576096534 CA1229916	50	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs371542831 CA1229915	50	F>S		No	ClinGen ESP ExAC gnomAD
CA1229920 rs749206057	54	V>I		No	ClinGen ExAC TOPMed gnomAD
rs770949861 CA1229921	55	L>*		No	ClinGen ExAC gnomAD
CA1229922 rs770949861	55	L>S		No	ClinGen ExAC gnomAD
rs1179051863 CA343085335	56	R>G		No	ClinGen gnomAD
rs1236989574 CA343085400	57	I>M		No	ClinGen gnomAD
CA1229923 rs759348099	60	G>E		No	ClinGen ExAC TOPMed gnomAD
CA343085771 rs1335065339	68	N>S		No	ClinGen TOPMed
CA1229925 rs375553827	70	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
COSM207668 rs760294386 CA1229926	72	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA343085932 rs1558162349	74	R>K		No	ClinGen Ensembl
rs758938659 CA1229929	75	C>R		No	ClinGen ExAC TOPMed gnomAD
CA343085963 rs1376312985	75	C>Y		No	ClinGen gnomAD
CA343086024 rs1459578508	77	N>K		No	ClinGen TOPMed
rs1030012310 CA31457228	78	N>Y		No	ClinGen TOPMed
CA31457231 rs952993404	79	Y>H		No	ClinGen TOPMed
CA343086403 rs1447565734	90	E>K		No	ClinGen gnomAD
rs1311817536 CA343086449	92	Q>K		No	ClinGen gnomAD
rs766811520 CA1229930	93	E>D		No	ClinGen ExAC gnomAD
rs937328464 CA31457477	96	T>A		No	ClinGen TOPMed gnomAD
CA1229948 rs61744533	96	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs917498929 CA31457482	98	G>A		No	ClinGen TOPMed gnomAD
CA343086843 rs776016165	98	G>R		No	ClinGen ExAC gnomAD
rs776016165 CA1229949	98	G>S		No	ClinGen ExAC gnomAD
CA343086869 rs1360666347	99	E>D		No	ClinGen gnomAD
CA343086877 rs1363307956	100	H>L		No	ClinGen TOPMed
CA343086879 rs1363307956	100	H>R		No	ClinGen TOPMed
CA1229950 rs761244356	100	H>Y		No	ClinGen ExAC gnomAD
CA343086897 rs1319195489	101	S>C		No	ClinGen gnomAD
CA1229951 rs766934400	101	S>P		No	ClinGen ExAC gnomAD
CA343086972 rs752044854	104	V>F		No	ClinGen ExAC gnomAD
rs752044854 CA1229952	104	V>I		No	ClinGen ExAC gnomAD
rs759942366 CA1229953	105	I>M		No	ClinGen ExAC gnomAD
rs1487973524 CA343087045	107	P>A		No	ClinGen gnomAD
rs148311054 CA1229957	116	Y>D		No	ClinGen ESP ExAC gnomAD
TCGA novel	117	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	123	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	124	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1007306829 CA31457516	125	L>F		No	ClinGen gnomAD
CA1229958 rs753974254	125	L>H		No	ClinGen ExAC TOPMed gnomAD
rs1211303368 CA343089411	129	V>I		No	ClinGen gnomAD
CA31460784 rs372428067	130	V>I		No	ClinGen Ensembl
rs780921720 CA1229971	133	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1377400270 CA343089502	133	T>K		No	ClinGen TOPMed
rs761366919 CA1229972	134	D>N		No	ClinGen ExAC TOPMed gnomAD
CA1229973 rs769267756	135	H>P		No	ClinGen ExAC gnomAD
TCGA novel	135	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	137	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343089606 rs1442373030	139	E>Q		No	ClinGen TOPMed gnomAD
CA343089925 rs1166726533	150	F>L		No	ClinGen TOPMed
rs1051867321 CA31460814	153	V>I		No	ClinGen TOPMed gnomAD
CA31460835 rs767516821	160	L>R		No	ClinGen Ensembl
CA343090205 rs1286257453	164	G>E		No	ClinGen gnomAD
TCGA novel	167	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1156680360 CA343090275	167	S>R		No	ClinGen gnomAD
CA1229979 rs764291936	169	S>R		No	ClinGen ExAC gnomAD
rs1423235090 CA343090432	172	I>M		No	ClinGen TOPMed
rs757463299 CA1229981	172	I>T		No	ClinGen ExAC gnomAD
CA343092276 rs1477742589	174	V>E		No	ClinGen gnomAD
CA1230003 rs764532151	174	V>I		No	ClinGen ExAC TOPMed gnomAD
rs530840370 CA31464300	177	S>C		No	ClinGen TOPMed gnomAD
CA31464311 rs367553853	178	S>G		No	ClinGen ESP
rs762161696 CA1230006	184	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs777036548 CA1230005	184	R>W		No	ClinGen ExAC gnomAD
rs765509729 CA1230007	185	F>V		No	ClinGen ExAC gnomAD
rs1572436980 CA343092676	192	V>G		No	ClinGen Ensembl
rs766282474 CA1230010	192	V>M		No	ClinGen ExAC TOPMed gnomAD
CA1230012 rs751488353	199	T>K		No	ClinGen ExAC TOPMed gnomAD
rs751488353 CA343092840	199	T>M		No	ClinGen ExAC TOPMed gnomAD
CA1230011 rs751488353	199	T>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs542882842 CA31464327	200	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1289504737 CA343092948	203	H>Y		No	ClinGen gnomAD
rs1247053027	205	A>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1186262130 CA343093830	205	A>T		No	ClinGen gnomAD
CA1230032 rs751552308	208	T>A		No	ClinGen ExAC gnomAD
rs759490884 CA1230033	209	Y>H		No	ClinGen ExAC gnomAD
rs1420138780 CA343093869	210	M>I		No	ClinGen gnomAD
CA1230034 rs765306922	210	M>L		No	ClinGen ExAC TOPMed gnomAD
rs1325075001 CA343093883	212	R>Q		No	ClinGen TOPMed
TCGA novel	213	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	214	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1230035 rs752492412	215	T>M		No	ClinGen ExAC TOPMed gnomAD
CA343093919 rs1333620722	217	R>Q		No	ClinGen gnomAD
CA343093971 rs1454620575	219	S>N		No	ClinGen TOPMed gnomAD
CA343093981 rs1307436513	219	S>R		No	ClinGen gnomAD
CA1230038 rs753509670	220	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	222	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343094129 rs1240230319	225	M>T		No	ClinGen gnomAD
CA343094359 rs1471032314	226	H>R		No	ClinGen gnomAD
rs1348389554 CA343094391	228	P>L		No	ClinGen TOPMed
CA1230051 rs144016855	229	P>R		No	ClinGen ESP ExAC gnomAD
CA1230053 rs760512618	230	S>F		No	ClinGen ExAC gnomAD
rs1038788182 CA31466200	231	L>H		No	ClinGen TOPMed
CA1230054 rs763920417	231	L>V		No	ClinGen ExAC TOPMed gnomAD
CA343094468 rs1326202616	233	T>M		No	ClinGen gnomAD
CA343094509 rs1427059050	235	P>R		No	ClinGen TOPMed
CA1230056 rs756959228	238	I>K		No	ClinGen ExAC gnomAD
rs779054395 CA1230057	239	S>F		No	ClinGen ExAC gnomAD
CA1230058 rs749962048	240	Q>R		No	ClinGen ExAC gnomAD
CA1230060 rs781775909	247	A>T		No	ClinGen ExAC TOPMed gnomAD
rs748631632 CA1230061	249	C>G		No	ClinGen ExAC gnomAD
rs1250770452 CA343095002	253	I>R		No	ClinGen TOPMed
rs1558166866 CA343094990	253	I>V		No	ClinGen Ensembl
rs746302570 CA31466228	257	R>K		No	ClinGen TOPMed
rs368864556 CA1230065	264	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA343095222 rs1314276870	266	Q>H		No	ClinGen TOPMed
rs771188615 CA1230066	266	Q>K		No	ClinGen ExAC gnomAD
TCGA novel	267	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343095252 rs1386576626	268	S>G		No	ClinGen gnomAD
TCGA novel	268	S>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs892544453 CA343095261	268	S>R		No	ClinGen gnomAD
rs1302365354 CA343095273	269	T>A		No	ClinGen TOPMed
CA343095310 rs1372338072	271	V>M		No	ClinGen gnomAD

No associated diseases with O75663

No regional properties for O75663

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O75663

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name	Definition
DNA damage checkpoint signaling	A signal transduction process that contributes to a DNA damage checkpoint.
negative regulation of phosphoprotein phosphatase activity	Any process that stops or reduces the activity of a phosphoprotein phosphatase.
regulation of phosphoprotein phosphatase activity	Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.
TOR signaling	The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P34274	C02C2.6	TIP41-like protein	Caenorhabditis elegans	PR

10	20	30	40	50	60
MMIHGFQSSH	RDFCFGPWKL	TASKTHIMKS	ADVEKLADEL	HMPSLPEMMF	GDNVLRIQHG
70	80	90	100	110	120
SGFGIEFNAT	DALRCVNNYQ	GMLKVACAEE	WQESRTEGEH	SKEVIKPYDW	TYTTDYKGTL
130	140	150	160	170	180
LGESLKLKVV	PTTDHIDTEK	LKAREQIKFF	EEVLLFEDEL	HDHGVSSLSV	KIRVMPSSFF
190	200	210	220	230	240
LLLRFFLRID	GVLIRMNDTR	LYHEADKTYM	LREYTSRESK	ISSLMHVPPS	LFTEPNEISQ
250	260	270
YLPIKEAVCE	KLIFPERIDP	NPADSQKSTQ	VE