O75343

PR
Gene name
GUCY1B2
Protein name
Guanylate cyclase soluble subunit beta-2
Names
GCS-beta-2
Species
Homo sapiens (Human)
KEGG Pathway
EC number
4.6.1.2: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

87-162 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O75343

Entry ID Method Resolution Chain Position Source
AF-O75343-F1 Predicted AlphaFoldDB

3 variants for O75343

Variant ID(s) Position Change Description Diseaes Association Provenance
VAR_024469
rs9568497
 55 Y>C No UniProt
dbSNP
rs11841997
VAR_024470
 128 M>I No UniProt
dbSNP
rs1328361
VAR_022131
 316 N>H No UniProt
dbSNP

No associated diseases with O75343

4 regional properties for O75343

Type Name Position InterPro Accession
domain Adenylyl cyclase class-3/4/guanylyl cyclase 355 - 564 IPR001054
domain Heme NO-binding 2 - 84 IPR011644
domain Haem NO binding associated 187 - 376 IPR011645
conserved_site Adenylyl cyclase class-4/guanylyl cyclase, conserved site 496 - 519 IPR018297

Functions

Description
EC Number 4.6.1.2 Phosphorus-oxygen lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
guanylate cyclase complex, soluble Complex that possesses guanylate cyclase activity and is not bound to a membrane.

4 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
guanylate cyclase activity Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
cGMP-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
response to oxygen levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P33402 GUCY1A2 Guanylate cyclase soluble subunit alpha-2 Homo sapiens (Human) PR
10 20 30 40 50 60
MSGYDRMLRT LGGNLMEFIE NLDALHSYLA LSYQEMNAPS FRVERGADGK MFLHYYSDRS
70 80 90 100 110 120
GLCHIVPGII EAVAKDFFDI DVIMDILDMN EEVERTGKKE HVVFLIVQKA HRKMRKTKPK
130 140 150 160 170 180
RLQDSQGMER DQEALQAAFL KMKEKYLNVS ACPVKKSHWD VVRSIVMFGK GHLMNTFEPI
190 200 210 220 230 240
YPERLWIEEK TFCNAFPFHI VFDESLQVKQ ARVNIQKYVP GLQTQNIQLD EYFSIIHPQV
250 260 270 280 290 300
TFNIFSIRRF INSQFVLKTR REMMPVAWQS RTTLKLQGQM IWMESMWCMV YLCSPKLRSL
310 320 330 340 350 360
QELEELNMHL SDIAPNDTTR DLILLNQQRL AEIELSNQLE RKKEELQVLS KHLAIEKKKT
370 380 390 400 410 420
ETLLYAMLPK HVANQLREGK KVAAGEFKSC TILFSDVVTF TNICTACEPI QIVNVLNSMY
430 440 450 460 470 480
SKFDRLTSVH AVYKVETIGD AYMVVGGVPV PIGNHAQRVA NFALGMRISA KEVTNPVTGE
490 500 510 520 530 540
PIQLRVGIHT GPVLADVVGD KMPRYCLFGD TVNTASRMES HGLPNKVHLS PTAYRALKNQ
550 560 570 580 590 600
GFKIIERGEI EVKGKGRMTT YFLIQNLNAT EDEIMGRSKT PVDHKGSTQK ASLPTTKLQG
610
SVQPSCPEHS SLASWLL