O75005

PR
Gene name
vas2 (SPBC1709.02c, SPBC1734.18c)
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC1709.02c
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O75005

Entry ID Method Resolution Chain Position Source
AF-O75005-F1 Predicted AlphaFoldDB

No variants for O75005

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O75005

No associated diseases with O75005

4 regional properties for O75005

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 139 - 150 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 106 - 729 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 774 - 919 IPR013155
domain Valyl tRNA synthetase, anticodon-binding domain 728 - 865 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

3 GO annotations of biological process

Name Definition
cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
cytosolic valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA in the cytosol, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADKGCEAAQ SKDSSAPGSG EPRPKTEKEL ERERQKAAKL EKYHAKLAAK KAKEEARKPK
70 80 90 100 110 120
LDKKAKIASP VAEYVEKTTP GEKKVLQDLD SPALKSYNPK AVESAWYDWW VKSGFFEPEF
130 140 150 160 170 180
GPDGKPKKEG VFVITSPPPN VTGALHIGHA LTIAIQDSLA RWNRMLGKTV LFLGGFDHAG
190 200 210 220 230 240
LSTQSVVEKK LWYTQKKTRH DYPRDKFVDI VWEWKEEYHN RIKNQMSRLG GSFDWTREAF
250 260 270 280 290 300
TMDENLSRAV VETFVRLHEE NIIYRANRLV NWCTALQTTL SNLEVENVDV PGRTLLKVPG
310 320 330 340 350 360
YDEPVEVGVL TSIAYAVEGS DERIVIATTR PETLLGDTAV AVHPQDPRYK HLHGKFVKHP
370 380 390 400 410 420
FCNRSIPIIC DDIIVDMEFG TGAVKITPAH DPNDYEVGKR HNLEFINIFT DDGLLNENCG
430 440 450 460 470 480
EFAGMKRFTA RVKVVERLKE LGLFVGTKEN PMVIPLCGKT SDIIEPVMKP QWWVNQKEMA
490 500 510 520 530 540
AAAAEVVKSG EIEIAPDMSR REFIRWMENI QDWCISRQLW WGHRIPAYFV NLADEPSQDR
550 560 570 580 590 600
SEGRYWVTGR TLEQAEEKAK AAFPGKSFTL EQDEDVLDTW FSSGLWPFST LGWPKDTSDY
610 620 630 640 650 660
ENFYPTTLME TGWDILFFWI ARMVMLGLKL TGKIPFKRVF CHALVRDAQG RKMSKSLGNV
670 680 690 700 710 720
VDPIDVIEGI SLQALHDKLL VGNLDSREVE KAKKGQRLSY PKGIPQCGTD ALRFTLCSLT
730 740 750 760 770 780
TGGRDLNLDI LRVEGYRKFC NKLYNATKFA LGRLGSNFVP NKTADLTGNE SLVEKWIFHR
790 800 810 820 830 840
LNIAAAAMNK NMEEMNFLQA TSAVHQFWLY ELCDVYIENS KYLLSDGTEV QQESAKQTLY
850 860 870 880 890 900
TVLDNALRLM HPFMPYVTEE MWQRLPRRPG DKTQTIVKAA FPVERVDYSN EIAAKYYESI
910 920 930 940 950 960
ITVVHSTRSM MAENGIKSDA VVYIHPDEEH SKLITSESAS IQSLIKKCKT LSIVDNTFDS
970
DKCVKNEVLE GSTIFLERNN