O74990
Gene name |
cog4 (SPCC338.13) |
Protein name |
Conserved oligomeric Golgi complex subunit 4 |
Names |
COG complex subunit 4, Component of oligomeric Golgi complex 4 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC338.13 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O74990
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O74990-F1 | Predicted | AlphaFoldDB |
No variants for O74990
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O74990 | |||||
No associated diseases with O74990
1 regional properties for O74990
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Conserved oligomeric Golgi complex, subunit 4 | 163 - 482 | IPR013167 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell division site | The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. |
| cell tip | The region at the end of the longest axis of a cylindrical or elongated cell. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| Golgi transport complex | A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| retrograde transport, vesicle recycling within Golgi | The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDISINDCTD | ISQIKQRFHD | LQVESQRTDE | KLERLLSDAQ | PTEKFNSLIK | NMAERLVLFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GQIEELKDAF | CNTTIVSEEV | IERIKSVDRE | QNRIKECLLF | VRQVRDFKEC | LQDLNRAMHH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QQWEKAADLV | HRASSTSPAI | IEGKFAHAVV | PTAEQPLAPM | DTLKEITESL | HTLFWREFHK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AARNQDQKEI | TRYFKLFPLI | GKEKEGLEAY | WHFFGGIIAS | KARATLDEPP | THALFFAQAF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TGLVEHVASI | IRAHTPLVQK | YYKAKNTITV | IEKLQGDCDR | QGSIIVNTMF | DVRRIDNLVS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SIASYKYILL | HAKLKNRAFV | SDQKELERVS | LQTLHPILNE | MSAIVSKWNI | SKIFISRLVL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RLSQSDGTSN | DPSVQDNLIC | ASIFNSSKME | LLLKKQLLPS | LLQLETYYFR | RSIETSLELE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EYYTKVSPWM | SSIVDDVMYV | TKQVFQRAFF | TVSSLFFTRF | VNESLIPILR | NDYYVYLSHN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLTVCNIIKA | QFQRLKNANS | IPAKQVENYI | TLVNSASLSK | QYLKSIVDGV | SSRLEEVFAF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AKDQKLVKKS | IDNFLQLTVN | FENLCKTSFN | MYFPIFLLPR | IEQCIDDSFD | GINYVLSYED |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YTKETEHERL | VVTRLRSVWD | RVLLLEQFTP | ENQLSLRSMA | CEKAASYIEN | LILYKIQWND |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YGAMALENDI | SSLITIFSND | QANLRHSFER | LQEILILLVW | ESDSTAPEQL | INDLNLQLLS |
| 730 | |||||
| IDIVSAIMEK | KANVQGED |