O74975
Gene name |
SPCC1827.02c |
Protein name |
Probable choline-phosphate cytidylyltransferase |
Names |
CTP:phosphocholine cytidylyltransferase, CCT, CT, Phosphorylcholine transferase |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC1827.02c |
EC number |
2.7.7.15: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O74975
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O74975-F1 | Predicted | AlphaFoldDB |
No variants for O74975
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O74975 | |||||
No associated diseases with O74975
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.15 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| choline-phosphate cytidylyltransferase activity | Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline. |
| phosphatidylcholine binding | Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| CDP-choline pathway | The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGEEGIKIND | THKRRIDEVE | PSEKEDNVER | QTKKYNFEID | EPEEQEKKDE | KEDDKEESPS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KSLEEISQSV | SPVEEEPRDV | RFKELSTPFS | YPINDPPEGR | PVRVYADGVF | DLFHIGHMRQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LEQAKKVFPN | VHLIVGLPND | QLTHRLKGLT | VMNDKERAEA | LRHCKWVDEV | LENAPWVITP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EFLEEHKIDF | VAHDDIPYAS | DDSGDIYLPV | KKVGKFIPTK | RTEGVSTSDL | ITRIIRDYDQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YVMRNLARGV | NRKELNVSLF | KKNELDLRHH | IKVLRDTLRN | HWVSTTRDLK | ADIKSFLSMA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TTDYQLQKNP | LHGSSEPSSP | GPTGFLGGIN | RWMQRRSSSH | YDLPRVGNEI | AASSSSATEE |
| NH |