O74894

PR
Gene name
rpt3 (SPCC576.10c)
Protein name
26S proteasome regulatory subunit 6B homolog
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC576.10c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O74894

Entry ID Method Resolution Chain Position Source
AF-O74894-F1 Predicted AlphaFoldDB

No variants for O74894

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O74894

No associated diseases with O74894

4 regional properties for O74894

Type Name Position InterPro Accession
domain AAA+ ATPase domain 167 - 306 IPR003593
domain ATPase, AAA-type, core 171 - 303 IPR003959
conserved_site ATPase, AAA-type, conserved site 274 - 292 IPR003960
domain Proteasomal ATPase OB C-terminal domain 58 - 113 IPR032501

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear periphery The portion of the nuclear lumen proximal to the inner nuclear membrane.
proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
proteasome-activating activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

3 GO annotations of biological process

Name Definition
CENP-A containing chromatin assembly The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres.
positive regulation of mitotic metaphase/anaphase transition Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNSTEEIDLY NRWKALERQL EMLDLQEGFI KEDCKSLKRE LIRAQEEVKR IQSVPLVIGQ
70 80 90 100 110 120
FLEAIDQNTA IVGSTTGSNY VVRILSTLDR ELLKPSASVA LQRHSNALVD ILPPEADSSI
130 140 150 160 170 180
SMLRPDERPD VSYADVGGLD VQKQEVREAV ELPLTQGDLY RQIGIDPPRG VLLYGPPGTG
190 200 210 220 230 240
KTMLVKAVAN STAANFIRVV GSEFVQKYLG EGPRMVRDVF RMARENAPAI IFIDEIDAIA
250 260 270 280 290 300
TKRFDAQTGA DREVQRILIE LLTQMDGFDQ GANVKVIMAT NRADTLDPAL LRPGRLDRKI
310 320 330 340 350 360
EFPSYRDRRQ RRLVFQTITA KMLLSPEVDL DTFIMRPDAS SGAQIAAIMQ DAGLLAVRKS
370 380
RGVILQSDIE EAYARAVKPT DMEQFAFYK