O74874
Gene name |
ccr4 (SPCC31H12.08c, SPCC5E4.02c) |
Protein name |
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4 |
Names |
Carbon catabolite repressor protein 4, Cytoplasmic deadenylase, Glucose-repressible alcohol dehydrogenase transcriptional effector |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC31H12.08c |
EC number |
3.1.13.4: Exoribonucleases producing 5'-phosphomonoesters |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O74874
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O74874-F1 | Predicted | AlphaFoldDB |
No variants for O74874
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O74874 | |||||
No associated diseases with O74874
No regional properties for O74874
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O74874 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.13.4 | Exoribonucleases producing 5'-phosphomonoesters |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| CCR4-NOT complex | The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8. |
| CCR4-NOT core complex | The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P-body | A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| poly(A)-specific ribonuclease activity | Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| nuclear-transcribed mRNA poly(A) tail shortening | Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFNPRYTQGT | IYPGAHPGLL | TPDHQHAAIL | SVQNSPALEN | SNISEHWKQQ | IALATQSRSF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSPHQRAHNA | AALARSGGPG | FSMNYNARTG | AFTGGPNAAG | LSSLGGKYNT | SSTTTTLTTS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TTLNTSSGTT | LNSTSKTTTS | SVAVDDQKSK | SDSKKERRDW | TCLDLGGIGL | RNVSTDLFKF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SFLTELYINH | NNLTRLPPEI | GKLKNLVILD | ASGNSIKTIP | PELGLLTELR | EVLLFDNMIS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VIPAELGTLF | QLKILGIEGN | PLQDVYKNQI | MESGTAGLIA | ALRDGCPVGP | PPPERGWEKL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VSDDDDDVND | NVSTSVRDLT | AADSNKPSTT | SKNLKFTIMS | YNVLCERYAT | STLYGYTPSW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ALSWSYRKDL | IMQELGGYNA | DIICLQEVDV | ENYDTFFAPQ | MSLKGYKGVH | FPKSRVRTMN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EVERRIVDGC | ATFFKTSKYV | MHEKMVIEYN | QAPSLRRQDI | KLTSNMYNRV | MTKDNISVIT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLENKENGSR | LIVANCHIHW | DPQFRDVKVI | QVAMLMDEIA | QVATKFRNMP | SKIPSDQLKD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ERPTYPEYLK | IPILICGDFN | SVQGSGVYDF | LSSGSISQNH | EDFMNNDYGE | YTVNGRSHAF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NLKSAYGESE | ALSFTNYTPG | FKGAIDHIWY | TGNSLEVTGL | LKGVDKDYLS | GVVGFPNAHF |
| 670 | 680 | ||||
| PSDHICLLAE | FKVKQEKTPL | PSSKFNNDKK |