O74855
Gene name |
rsa4 (SPCC18.05c) |
Protein name |
Ribosome assembly protein 4 |
Names |
Notchless protein homolog 1, Ribosome biogenesis factor rsa4 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC18.05c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O74855
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O74855-F1 | Predicted | AlphaFoldDB |
No variants for O74855
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O74855 | |||||
No associated diseases with O74855
13 regional properties for O74855
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | G-protein, beta subunit | 427 - 443 | IPR001632-1 |
| domain | G-protein, beta subunit | 446 - 460 | IPR001632-2 |
| domain | G-protein, beta subunit | 483 - 500 | IPR001632-3 |
| repeat | WD40 repeat | 123 - 305 | IPR001680-1 |
| repeat | WD40 repeat | 299 - 374 | IPR001680-2 |
| repeat | WD40 repeat | 378 - 502 | IPR001680-3 |
| domain | NLE | 31 - 94 | IPR012972 |
| conserved_site | WD40 repeat, conserved site | 242 - 256 | IPR019775-1 |
| conserved_site | WD40 repeat, conserved site | 283 - 297 | IPR019775-2 |
| conserved_site | WD40 repeat, conserved site | 446 - 460 | IPR019775-3 |
| repeat | G-protein beta WD-40 repeat | 242 - 256 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 283 - 297 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 446 - 460 | IPR020472-3 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| ribosomal large subunit assembly | The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATLLPPKSK | RQKKESLNPT | TIEIPEKFPL | VNVQFRASDD | SNELASLLVP | GNSSVRQLEA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLNQLLENSD | DPVPYNFALH | HEDETIEIQD | NLYTSVFHNG | LMKTEDHLTL | LYTPQAVFRV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RAVTRCTASM | NGHDGTIISA | QFSPSTSSRL | VTGSGDFTAR | LWDCDTQTPI | ATMKGHTNWV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SCVAWAPDAS | IIATGSMDNT | IRFWDPKKGS | PIGDALRRHT | KPIMALCWQP | LHLAPDSGPY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLASGSKDNT | VRIWNVKLRT | LLFTLSGHTA | PITCVRWGGQ | NWIYSSSYDK | TIRIWDAKDG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KCLHILKGHA | ARVNHLSLST | EHVLRSGAYD | HTDFKPKSFS | DERRKAKERY | EACLKQSGER |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LVSASDDLQL | ILWDPQKSTK | PITKMHGHQK | VVNHASFSPD | GRCIATASFD | SSVRLWDGKT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GKFLATLRGH | VAAVYQCAWS | TDSRLLVSSS | QDTTLKVWDV | RSKKMKFDLP | GHEDQVFAVD |
| 490 | 500 | ||||
| WSPDGQRVAS | GGADKAVRIW | SH |