O74839
Gene name |
msy1 |
Protein name |
Mechanosensitive ion channel protein Msy1 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC1183.11 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O74839
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O74839-F1 | Predicted | AlphaFoldDB |
No variants for O74839
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O74839 | |||||
No associated diseases with O74839
1 regional properties for O74839
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 543 - 578 | IPR002048 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| perinuclear endoplasmic reticulum | The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| stretch-activated, cation-selective, calcium channel activity | Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transmembrane transport | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| cell volume homeostasis | Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. |
| cellular calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSPTSPTSS | PGRHHWSNSK | DGMPPEYTNQ | DPNSDQADNE | NSDAKAHQPQ | HSPQHSTENQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GHTGTSDTSS | LEMELSKLHP | ESKQRQLPHS | PEHERSRSPI | ASVVSYRSHM | TLEDENQIFN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AEMAVRGSQS | LQRRPTGRSV | RGSMRRLSSH | RSKSMRTSKS | KKSGDYERTA | ENEEAAQEAE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NHLDNFGVVT | FGTEAPIKAP | DHPVTIFGRI | FKFIQQRSFY | LRSLIYIIPL | GVLLLIPVFI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GRFYHPQPPY | RDELGHEYER | HLHVGGVDLM | WMAIWWEIIW | LSIWAARYAA | KVIPYFFAFF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VSFISNNVTK | WRCMAVALEF | PITLFLWMLA | VYVSFLPIMT | RRHIGDYGVP | DHVRVKLPWQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QSANNVLITL | FITSIMNLVE | KVLMQLIAMS | LHRREYESRI | LYNKFAINEL | ARLYGYARQR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SFDFKDAIHR | AQADVFKFAD | HQHGKKRAAA | ARVAQNALNK | TTYKAISAFN | FATDMVNKVA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GEITNREVEK | SSSPKSVVLH | LLKTTRGCQS | LARCLFEALV | NPENPDLVLD | DFIPVYTDET |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GEVDNATLEA | CYSIFDRDLN | GDITCEEIEL | ACVEIGKERK | SISASLRDLN | DSISKLDGIC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MFIVAVITLF | IFLYLIARNF | SGVLTSAGTT | LLGLSWLFSG | SAQELLSSII | FVFVKHPYDV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GDRVDVMING | TVTSAMVKEI | SIMSTEFRLL | TGKVIQAPNS | LLNTLWILNM | RRSDGIADPV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TVNLKFGTTL | QQIEQLRIKI | IDFLKEEKRD | YKPDLLTEVT | DLPDLYSMSL | CVVFFHKYNF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QDEVLRMRRR | NMFMCALMTY | MQELDIVSPI | FNSPGKSKDS | PMYVNFNNGS | MEGVKLSGGN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DGGGTENHRD | STVGGGILKN | PKAYPYREPT | PPGSSDSDTA | SVSKKRVDFS | LGTRHLMPAF |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DDVADIGSKR | LGRDSLPDAV | IENAGTEAMR | REAEERRRAE | EEEYERSQQE | SSSNEENENA |
| 970 | 980 | 990 | 1000 | 1010 | |
| SRTSGARFSF | SSKASRLSAR | PSARTVPPLQ | HISIQDLREP | NENNTSKSAR | L |