O74760

PR
Gene name
tif32 (eif3a, SPBC17D11.05)
Protein name
Eukaryotic translation initiation factor 3 subunit A
Names
eIF3a, Eukaryotic translation initiation factor 3 110 kDa subunit, eIF3 p110, Translation initiation factor eIF3, p110 subunit
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC17D11.05
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

799-880 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O74760

Entry ID Method Resolution Chain Position Source
AF-O74760-F1 Predicted AlphaFoldDB

No variants for O74760

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O74760

No associated diseases with O74760

1 regional properties for O74760

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 309 - 506 IPR000717

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
eukaryotic translation initiation factor 3 complex, eIF3e An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.
eukaryotic translation initiation factor 3 complex, eIF3m An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m.
multi-eIF complex A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.

2 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

2 GO annotations of biological process

Name Definition
formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
translation reinitiation A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAPPQGKPEN VLRLADELIA LDQHSSALQS LHETIVLKRS RNAQGFSLEP IMMRFIELCV
70 80 90 100 110 120
HLRKGKIAKE GLYTYKNAVQ NTSVTAIENV VKHFIELANK RVQEAQEKAD KISVEYVDDL
130 140 150 160 170 180
EATETPESIM MSLVSGDLSK SRTDRALVTP WLKFLWDAYR TVLDILRNNA RLEVMYQLIA
190 200 210 220 230 240
NSAFQFCLKY QRKTEFRRLC ELLRSHLGNA SKFSNAPHSI NLNDAETMQR HLDMRFSQLN
250 260 270 280 290 300
VAVELELWQE AFRSIEDIHS LLTFSKRAPA AVMLGNYYRK LIKIFLVCDN YLLHAAAWNR
310 320 330 340 350 360
YFTFTNVQKP ATANFVILSA LSIPIIDANK LSGPSIEAED AKSKNARLAL LLNLSKTPTR
370 380 390 400 410 420
ETLIKDAISR GVLSFCDQAI RDLYQILEVE FHPLSICKKL QPIIKRLAES NDTAQYIRPL
430 440 450 460 470 480
QQVILTRLFQ QLSQVYDSIS LKYVMDLATF EEPYDFNPGQ IEKFIMNGNK KGAFSIRLNH
490 500 510 520 530 540
IENSISFSSD LFSNPIKSSD SVSLQSTPSE LITSQLTRIA KSLSSVLMRF DTDFCLLRKQ
550 560 570 580 590 600
QAEAAYERAQ AGVEQERKAV IAQRSLLELR RGQADTLATQ REAELAAQRA LKQKQESEAE
610 620 630 640 650 660
SLRVQEEINK RNAERIRREK EAIRINEAKK LAEELKAKGG LEVNAEDLEH LDADKLRAMQ
670 680 690 700 710 720
IEQVEKQNKS MNERLRVIGK RIDHLERAYR REAIPLWEED AKQQAEHDRE IFYEREKQRK
730 740 750 760 770 780
EVQERKHEQA IKDKKAFAQF ASYIHAYKQN IDDERDKAYQ EAYAKAKNVI DAERERQRKE
790 800 810 820 830 840
IFEQKLAEAI REAEEEAARA AEEEANRELH EQEEAQKRAI EERTRAAREA KEREQREMAE
850 860 870 880 890 900
KLERQRRIQQ ERDEEISRKL AEKAAARRAN IGASSPSPGA WRRGGASAGG VSRDSPRYSR
910 920 930
GGYSRGSVPP RETLAPSKGA YVPPSRRNQQ QQ