O74755

PR
Gene name
pst3 (SPBC1734.16c)
Protein name
Paired amphipathic helix protein pst3
Names
SIN3 homolog 3
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC1734.16c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

326-407 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for O74755

Entry ID Method Resolution Chain Position Source
8I03 EM 320 A B 1-1154 PDB
AF-O74755-F1 Predicted AlphaFoldDB

No variants for O74755

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O74755

No associated diseases with O74755

4 regional properties for O74755

Type Name Position InterPro Accession
repeat Paired amphipathic helix 111 - 181 IPR003822-1
repeat Paired amphipathic helix 252 - 322 IPR003822-2
domain Histone deacetylase interacting domain 492 - 592 IPR013194
domain Sin3, C-terminal 885 - 1096 IPR031693

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
Clr6 histone deacetylase complex I'' A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
histone deacetylase complex A protein complex that possesses histone deacetylase activity.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Rpd3L complex A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae).
Rpd3L-Expanded complex A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.
Sin3-type complex Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.

1 GO annotations of molecular function

Name Definition
transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

5 GO annotations of biological process

Name Definition
chromatin remodeling A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
histone deacetylation The modification of histones by removal of acetyl groups.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDVMNVPVDS ERDNPGDKVE TQSDKNHLPK ASPSQSQSPV NTSLHNGDGK DNGVATEPVE
70 80 90 100 110 120
NKQILSERSV TRDDYEKGKT IVSSLALSSI SGKDGSISSQ NAEGLSSSSN RPLDVNDALS
130 140 150 160 170 180
YLELVKYYFS ERREIYNRFL EIMRDFKSQA LDTLGVINRV SELFNGYPQL IEGFNTFLPS
190 200 210 220 230 240
GYKIEVQLDS SNTSVVRVGT PMHPLPQQGV QSTLPVAPSN EDQRTMESTS PTDSQPQPSA
250 260 270 280 290 300
PNLVSSTENE KPRVDFNYAI AYMNKVKARY PPNSDTYMEF LGVLRTYQKA QKSIFEVRAR
310 320 330 340 350 360
VAEIFKDSPD LLEEFKLFLP DNVDSTEPST PNVQKSPNRL PPVGNFSLPP SAPVREKRNR
370 380 390 400 410 420
PAHSAQISRS ISKTSRMYRQ TAEEPLNSYS LHVYPQKITA PTSPYAATQE ELLAFTTIRQ
430 440 450 460 470 480
HLPDTLAFHK FLELLHLYRE KLLDKTELLN SFSKLVRNDN LTLWFSEFIR WSDNPILVKN
490 500 510 520 530 540
EPVDERVYLP ETFECISLTY RKLPDSWKQD KCSGRDDLDN SVLNDDYISV APKPSHVKNI
550 560 570 580 590 600
MHHENQYLQA LQLVEDERYD YDRVLNTTES AIKILANFCE PTIHEHLETA LQELERSKRI
610 620 630 640 650 660
IKNALIIVYG KEHANLALDT LFKKLPTAAP VLLKRIKTKD QEWRRSKREW SKIWRQIEKK
670 680 690 700 710 720
NAQAAFDDRY CRIEGRDRRG LSYSRILRDI DDIYQRQKHR IDGAKLGFQF TQVLCDSLIF
730 740 750 760 770 780
LNILRLSDAQ LTNSSFYSYA DKGRISAVLK ALLSQFFGIP LPREALETNL ASENIESVKK
790 800 810 820 830 840
HRDGLSKIFI RPESADNSNN TNVSFQTDET QTEDETMSDI HPDDVENHSK SKFLGEESKN
850 860 870 880 890 900
IIGYNFFGNA TMYVLFRLIC VCYSRLEHIK LFVESSTIYA SSTGGYENIL NICEKYLKGS
910 920 930 940 950 960
CSRLEFRKYL QKFNNETCYM ICSIERLLKV IFYRIHEILL DPKLGQLLLL FESDGANSVT
970 980 990 1000 1010 1020
TPREQMVYRN HVESILAPES KIFNMRWYPL EKRLCIQQLL PADLTMHDFE NPAKAFMYYV
1030 1040 1050 1060 1070 1080
DSYAISHITE GVDLMQVKMP FLRRSLQRIS QQGYLAGRGS GRLHSLFNEH FCKSNLQLFF
1090 1100 1110 1120 1130 1140
STDTYVIFFE PNTENVYINS YNLWVDQSSQ SKKQNRTTNW RRWLESDEGW RKSKANTDIK
1150
FFSETTLDQC IEAM