O74743

PR
Gene name
tif452 (SPBC1709.18, SPBC409.01)
Protein name
Eukaryotic translation initiation factor 4E-2
Names
eIF-4E-2, eIF4E-2, eIF-4F 25 kDa subunit 2, mRNA cap-binding protein 2
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC1709.18
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-83 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O74743

Entry ID Method Resolution Chain Position Source
AF-O74743-F1 Predicted AlphaFoldDB

No variants for O74743

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O74743

No associated diseases with O74743

1 regional properties for O74743

Type Name Position InterPro Accession
conserved_site Eukaryotic translation initiation factor 4E (eIF-4E), conserved site 118 - 141 IPR019770

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
eukaryotic translation initiation factor 4F complex The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.

2 GO annotations of molecular function

Name Definition
RNA 7-methylguanosine cap binding Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

2 GO annotations of biological process

Name Definition
cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADAEDSRHS KNEGFPNTSL ITEKLDLLDL FGSPKVKTER EGRPARLLEG LSAVNAETAF
70 80 90 100 110 120
VKTHPLQHEW TLWFLKPPTQ GLEWSDLLKE IISFKTVEEF WGIFKTISKA SMLPAKSDYS
130 140 150 160 170 180
YFLKGIRPEW EDPQNMNGGK WAYQSKHKGS NLDELWLYMV LAAIGETLDP TGKEVTGVVC
190 200 210 220 230 240
NMRKGFYRIA VWTRNCNDKD VLEKIGLRFK EVLGISDKET IEYSAHEDSS KAGSMRAKTR
MSL