O74560
Gene name |
raf2 (clr7, cmc2, dos2, SPCC970.07c) |
Protein name |
Rik1-associated factor 2 |
Names |
Cryptic loci regulator 7, De-localization of swi6 protein 2 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC970.07c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O74560
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O74560-F1 | Predicted | AlphaFoldDB |
No variants for O74560
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O74560 | |||||
No associated diseases with O74560
1 regional properties for O74560
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA (cytosine-5)-methyltransferase 1, replication foci domain | 8 - 147 | IPR022702 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| CLRC complex | An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| heterochromatin island | A region of facultative heterochromatin formed dynamically at specific loci in response to environmental signals, independently of RNAi. |
| mating-type region heterochromatin | Heterochromatic regions of the chromosome found at silenced mating-type loci. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| pericentric heterochromatin | Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3). |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| CENP-A containing chromatin assembly | The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres. |
| heterochromatin assembly by small RNA | A heterochromatin formation-based gene silencing process mediated by a small RNA molecule that occur before the beginnning of trancription. |
| pericentric heterochromatin assembly | The compaction of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by methylation of histone H3K9, into heterochromatin, resulting in the repression of transcription at pericentric DNA. |
| silent mating-type cassette heterochromatin assembly | Repression of transcription at silent mating-type loci by alteration of the structure of chromatin. |
| subtelomeric heterochromatin assembly | The compaction of chromatin into heterochromatin at the subtelomeric region. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPPVRAEKKR | KTDLIEQVCV | TNKAGELVDL | EDVLEYGPYS | LTGILSSEKD | EQEPLFDESI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLGYSIKISP | VWTYNLKDVP | EKETMSIWIV | TPQRRYGILS | PSSEYKAIYE | QISEKNRLFY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LIKTKFKDDM | ISGTLEDYDN | YIEVLKEKLE | LPSCFQAILL | VQKHIRFLLT | QMVATSSLHV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WSESPFFIRI | RSSYEHLILQ | INKNIYNARQ | ERKKSKLSSN | NPSDNNTTMK | SSLNQALTLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NLPEQPFSIS | SPTATPQLGV | VKRTSPLRFP | LNDIWLSGLR | IVDPNIESIS | LWKRIQVSTS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PKHQRYISLQ | EVCSVIAQQL | QITNLEALNK | LSSHGETLLQ | IMHTAFTWRG | TKLFNDIKHA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IGFRSSVQQA | RSQFRGYCYD | YLFMHCNNGE | KTSLHLLRTL | ICMKLDFSNA | QLAAKILFHF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLFDIGSGLS | GSDYTYEQYI | NHSAVAFSFT | EEIFEKNFVT | VLPDFVKLFS | ISFGYWPAFS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FYDELLKLLR | NKYPKVYSST | PNLCDQVWLD | RTNLFPCNRS | TRSTLPYRPT | KLLDLASASS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CLSKKETDFK | QDTGLYSYNL | EKVEALKVSP | DLQTGIWSCP | VQNCLYFAVC | DNPYKPSQVI |
| 610 | 620 | 630 | |||
| YDHLLGHVDS | KFIFKTPSNS | VRSFTNKLEH | IMYNIN |