O74548

PR
Gene name
arg1 (SPCC777.09c)
Protein name
Probable acetylornithine aminotransferase, mitochondrial
Names
ACOAT
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC777.09c
EC number
2.6.1.11: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O74548

Entry ID Method Resolution Chain Position Source
AF-O74548-F1 Predicted AlphaFoldDB

No variants for O74548

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O74548

No associated diseases with O74548

No regional properties for O74548

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O74548

Functions

Description
EC Number 2.6.1.11 Transaminases
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

4 GO annotations of biological process

Name Definition
arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.
glutamate catabolic process The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.
ornithine biosynthetic process The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFQRRSLLSV RSSGSQIAFR RFVSLTHKDP TPDTTSCNII KKEGANIISV YARYPVVAAK
70 80 90 100 110 120
GEGSYLFDKE GRKYIDFTSG VAVTSLGHAH PEVARLAADQ CSKLVHSSNL FYNEPAIELS
130 140 150 160 170 180
NVINNSLAKN SGIAGPTKIF FANCGTEANE TALKFARKAA FEKYGEGKSQ IVYFNNSFHG
190 200 210 220 230 240
RSLGSLSITA NPKYKRGFQP LLPDVVQAVY NDPASIEQFV NDKTAAVIVE PVQGEGGICP
250 260 270 280 290 300
AKPEFLIALR KACDKVGASL IYDEIQCGLG RSGDLWAHSI VKDVASPDII TVAKPLANGL
310 320 330 340 350 360
PIGATIVSSK IAAEIHPGEH GSTFGGNPVA CRVGTFCVNE LGSSKILQNV RKQHKALTSR
370 380 390 400 410 420
FDDFVAKYPN LIRGYAGRGL LLGLQFTEPP AKFIELARQQ GLLLLPGGNN NTRVLPSLNV
430 440
KDEVIAKGLD IMESTLKALS K