O74536

PR
Gene name
ssp2
Protein name
SNF1-like protein kinase ssp2
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
spo:SPCC74.03c
EC number
5.6.1.1: Enzymes altering polypeptide conformation or assembly
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

303-351 (autoinhibitory region) EV

Target domain

34-285 (Protein kinase domain)

Relief mechanism

Ligand binding

Assay

Structural analysis, Mutagenesis experiment

Accessory elements

173-195 (Activation loop from InterPro)

Target domain

34-285 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

8 structures for O74536

Entry ID Method Resolution Chain Position Source
2OOX X-ray 260 A A/C 440-576 PDB
2OOY X-ray 288 A A/C 440-576 PDB
2QR1 X-ray 270 A A/C 440-576 PDB
2QRC X-ray 270 A A/C 440-576 PDB
2QRD X-ray 241 A A/C 440-576 PDB
2QRE X-ray 301 A A/C 440-576 PDB
3H4J X-ray 280 A A/B 25-351 PDB
AF-O74536-F1 Predicted AlphaFoldDB

No variants for O74536

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O74536

No associated diseases with O74536

1 regional properties for O74536

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 9 - 177 IPR005225

Functions

Description
EC Number 5.6.1.1 Enzymes altering polypeptide conformation or assembly
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cytoplasm
  • Cytoplasm, cytoskeleton, spindle
  • Cytoplasm, cytoskeleton, spindle pole
  • Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitotic spindle pole body The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
nucleotide-activated protein kinase complex A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

11 GO annotations of biological process

Name Definition
CAMKK-AMPK signaling cascade The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
induction of conjugation with cellular fusion The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of cytoplasmic translation Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation.
negative regulation of TORC1 signaling Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
positive regulation of ascus development Any process that activates, maintains or increases the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed.
positive regulation of cell cycle switching, mitotic to meiotic cell cycle Any process that activates or increases the frequency, rate or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein phosphorylation The process of introducing a phosphate group on to a protein.
SREBP signaling pathway The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELSYQALRV ASQNREAEEL RTEARRKNLL ILIMHYLLQE GYMDSANSLE QETKISLRRF
70 80 90 100 110 120
DVCDNVDLET ILMEYESYYY IKFQKYPKIT KKALDHDSRV QSKPRSAGKL RRAGSNSTQG
130 140 150 160 170 180
LPRIAQQTVL HRPVSGSYFR THAHQKALSR ENSKQENGGN SPREASEIGL NVSAISKTSG
190 200 210 220 230 240
EGGQTRRRQV IDFRSMIQDT IKGASQEIAL NSLNCNPDPS ERLIKPVGAF IGGNSEMREL
250 260 270 280 290 300
AAVISRDIYL QNPNVRWDDI IGLDAAKRLV KEAVVYPIRY PQLFTGILSP WKGLLLYGPP
310 320 330 340 350 360
GTGKTLLAKA VATECNTTFF NISASTIVSK WRGDSEKLVR VLFELARYHA PSTIFLDELE
370 380 390 400 410 420
SVMSQRGTGP GGEHEGSRRM KTELLVQMDG LARSDDLVFV LAASNLPWEL DYAMLRRLEK
430 440 450 460 470 480
RILVDLPSKE ARQAMIQHWL PPVSNSSGVE LRTDLDYSTL GAETDGYSGS DIRLVCKEAA
490 500 510 520 530 540
MRPVRKIFDA LENHHSEHKN LPVISLDTVT TSDFLEVLAH TKPSAKSLAE KYAAWQKEFE
SV