O74516
Gene name |
trm44 (SPCC663.10) |
Protein name |
tRNA (uracil-O(2)-)-methyltransferase |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC663.10 |
EC number |
2.1.1.211: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O74516
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O74516-F1 | Predicted | AlphaFoldDB |
No variants for O74516
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O74516 | |||||
No associated diseases with O74516
No regional properties for O74516
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O74516 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.211 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| tRNA (uracil) methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule. |
| tRNA (uracil-2'-O-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA methylation | The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKVPAYWKPR | EPKNALTCDP | PVPYDLQSSY | QWQSILEHDT | CYAAEVFDKM | MIELVYHPER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TSSVIMRTDI | ILDSQEDDSI | LNKQKSVFEN | LDERYQISRW | IDRRIIPRNT | NLDATMDQTV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VVLHEKLEND | RILMYLPHLD | KSLEQPYNHL | PYYHPAVAGI | AFHYKGSSVE | VLYLVEKDFQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RELSSRLLRT | AHMLLLVLHK | HCKGAVEGYQ | KRMLHDTVVE | RNKFQDTYVI | LKDKYAKQLV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DNWVEKTDPG | KHVFEDLAIA | AFLIELWKQT | YSSNKEFSFV | DVGCGNGLLV | YLLLMEGYNG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YGFDARKRKS | WETYPLWVQV | KLYEKVLVPY | FLHDFETKIP | FPQLPAGFTM | SAANIHDGRF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SENSFLIGNH | ADELTPYLPI | LARLNQKCYF | MSIPCCVHDL | TGAKISWALP | KPRNPKHGGR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YAMYIEWLMQ | LSEEVGWNIE | VEPLRIPSTR | NYALIGRKLL | SNDLLHSSLS | TDALYDIVEK |
| 490 | 500 | ||||
| NHGSQGFFVH | AMQVAAANSR | SH |