O74511

PR
Gene name
ekc1 (SPCC663.01c, SPCC777.16c)
Protein name
Extragenic suppressor of kinetochore protein 1
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC663.01c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

361-525 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O74511

Entry ID Method Resolution Chain Position Source
AF-O74511-F1 Predicted AlphaFoldDB

No variants for O74511

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O74511

No associated diseases with O74511

3 regional properties for O74511

Type Name Position InterPro Accession
conserved_site Enolase, conserved site 331 - 344 IPR020809
domain Enolase, C-terminal TIM barrel domain 135 - 413 IPR020810
domain Enolase, N-terminal 3 - 130 IPR020811

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Associated with chromatin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.

3 GO annotations of molecular function

Name Definition
protein phosphatase activator activity Binds to and increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.
protein phosphatase binding Binding to a protein phosphatase.
protein phosphatase regulator activity Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

5 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
negative regulation of protein localization to kinetochore Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to kinetochore.
regulation of mitotic chromosome condensation Any process that modulates the frequency, rate or extent of mitotic chromosome condensation.
regulation of phosphoprotein phosphatase activity Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFWRLGQGFG FQSSSAIEAI LDKPEDEINL KELLEENGVL DECKSHNPKL LEYLCKPEVL
70 80 90 100 110 120
SQLIDYILEV DETEIPSADG GYEEPEHTRL SYIASEILSS DVWSICEACV ENKTLMVKLW
130 140 150 160 170 180
SFLDSEGPLN PLQASYFAKV NEHFLDKKTE ETVAFIQSID NFVEKILRHA ETSAIMDLLL
190 200 210 220 230 240
KFISMDRCNT AIGIADWLYS QGLIQSLLRL LSPYVDPDVQ FTVADVIKAI IAISANSNEP
250 260 270 280 290 300
GVIGPNSLSR ELVSRQTITT LTDYMTDSKA PHSATSLING VSIVIELIRK NNSDYDVTPV
310 320 330 340 350 360
LQMPLDTHPP TTRDPIYLGT MLRLFAEKIP VFQKILLKPS TESDLMPTSF GKIKPLGFER
370 380 390 400 410 420
FRICELYAEL LHCSNMSLLS DPNGEAMVMQ RDHLRDYLFR HNSCARDLVM SDEDDDDSTF
430 440 450 460 470 480
SDKNSKDFKE TEDMNGAEDM HGRAPQITKD NLNLTTTDSP MSEAEPVSEE EYKDVMETAK
490 500 510 520 530 540
ALHHGDDDAA SDTSYEPLPE SVIEDAKKLP VIGDFLKIEF IQNNVIPTIL DHFFDYPWNN
550 560 570 580 590 600
FLHNVVYDVV QQVLNAPMDK DQNYALAVDM FKQGKITEKI VYGQELNDKK VAKPSGFRAG
610 620 630 640 650 660
YMGHLTIIAD EVVKFVEHYS STFDQELLNL INDEKWQNFV NKTLVETRNR DNQLLGGLEP
670 680 690 700 710 720
SMVGYLEDMD EGEMLDANNL PEMQFALEQE LESNSSDDDV VEVHRELSHN SSSNDEDDGN
730 740 750 760 770 780
DEDPLSREMS RRLSFESAND SDQDNRDHFA QYMSQQISDN NANQFSSSDE DDDDDDEVVE
790 800 810 820 830
WVSRGNENKY PRSNFFINGS DREDFSDSEE EDGNDSSDDD RGFAEEEYSD GLVLNHGK