O74508
Gene name |
spp1 (SPCC594.05c) |
Protein name |
Set1 complex component spp1 |
Names |
Set1C component spp1, COMPASS component spp1, Complex proteins associated with set1 protein spp1 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC594.05c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O74508
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O74508-F1 | Predicted | AlphaFoldDB |
No variants for O74508
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O74508 | |||||
No associated diseases with O74508
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Set1C/COMPASS complex | A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| methylated histone binding | Binding to a histone in which a residue has been modified by methylation. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| heterochromatin assembly | An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. |
| histone H3-K4 methylation | The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELTQENTEE | NEKTHVESIV | KFEDSNRGTI | TDFHIETANN | EEEKDANVIL | NKSVKMEVEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VNGHVDSSST | ETDIEMQVIQ | QPTIPKKPPV | SAHRRGPRKH | RGNANSQLNL | STADHQRPLY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CICQKPDDGS | WMLGCDGCED | WFHGTCVNIP | ESYNDLTVQY | FCPKCTEEGK | GITTWKRKCR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LRECSNPTRP | NSNYCSDKHG | VDFFREKVKL | STVEPSAIKN | LVLFAKKREE | FQNLGTVGPT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPSQVPPEVV | YNFEIEEANR | LNAEIVQLNK | EKEVASNKKI | FLQLIKDSSR | RAVLAYKERE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GIKKDLCGFD | SRLLFNQQQM | NELWEKVSNG | APLSLDMSID | PSPESTCFTE | KRRCAKHTSW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QVIFTEDFEL | QESNILQKLN | MKQTAKDVML | EHQKQRCLPG | IQYDGYARFC | HEQLSPEKMA |
| NLLK |