O74502

PR
Gene name
msh6 (SPCC285.16c)
Protein name
DNA mismatch repair protein msh6
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC285.16c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-387 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O74502

Entry ID Method Resolution Chain Position Source
AF-O74502-F1 Predicted AlphaFoldDB

No variants for O74502

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O74502

No associated diseases with O74502

5 regional properties for O74502

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 1017 - 1209 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 375 - 492 IPR007695
domain DNA mismatch repair protein MutS, core 671 - 1000 IPR007696
domain DNA mismatch repair protein MutS, connector domain 502 - 646 IPR007860
domain DNA mismatch repair protein MutS, clamp 835 - 923 IPR007861

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
MutSalpha complex A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
double-stranded DNA binding Binding to double-stranded DNA.
guanine/thymine mispair binding Binding to a double-stranded DNA region containing a G/T mispair.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

2 GO annotations of biological process

Name Definition
maintenance of DNA repeat elements Any process involved in sustaining the fidelity and copy number of DNA repeat elements.
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSVGNVGKQR EKTKDSSAKT KQKTLFGFFS KIPNVKQEKS DSTLSSSSNH DSNHDTPADV
70 80 90 100 110 120
DNSSNVNKNS SSPERELPTS PSHHANTEID SSSSMLPPPS SDPFSSPLSS SLHRSSPKRP
130 140 150 160 170 180
HDSLGEESPG KLLRTSVKQE PDSEEEIDSP TKKKSFKSLD TSIFQAEDQF RHPVSSKLEN
190 200 210 220 230 240
SELSEVDKPF IASRRSRKPV SYAESDEDED FDDAPTKGSR HKRIVSDDES DDYVEPDHIS
250 260 270 280 290 300
EASSEASLPI DEVESMDEDV DGYSDHSVSV AAPIPKKESR KESSNSLYES YRLGSQIASP
310 320 330 340 350 360
SPSVSGSASP TKSNKNGVLN REEKRRQRME AFKKENNERY EWLLDVRDAD QNRVGDPNYD
370 380 390 400 410 420
PRTLYIPPSA WATFKPFEKQ FWKIKKDLMD TVVFFQKGKF YELYENDAAI GHQVFSLKLT
430 440 450 460 470 480
DRVNMKMVGI PEASFDYWAS QFIAKGYRIA RVDQLETALG KEIKDRQRTQ KEEKVVQRGL
490 500 510 520 530 540
TQVLTSGTLV DEAMLTSDLS TYCMAIKESL QSDNEEPSFG ICFIDTSTGG FHMCEFTDDI
550 560 570 580 590 600
HRTKLDTLLT QVRPKELILE KSKISQKSIR AIKYCVSSSS IWNFIKPYTE FWDNERVERE
610 620 630 640 650 660
IIAGDYFKNG LEGAPKILKS YLSEKPLAIS AFGALFWYLR QLKLDKDMCS MGNFDEYDAS
670 680 690 700 710 720
QQSTSLLMNG QTLKNLEIFS NSFDGGSEGT LFHLLCRCVT PFGKRLFHTW LCHPLRSGTA
730 740 750 760 770 780
INARLDVVEL IADNPVIRDT IWGFLHKLPD LERLISRVHA GRSKPADFVR VLEGFQRINS
790 800 810 820 830 840
AFDQLREEFM EVAEGTLLGE IIQSAPNMKE ELEAWTRAFN WQKASEEGVF EPEIGFEAEY
850 860 870 880 890 900
DTSQKYQSEL KNELYALLEQ YKKQLRCSSL NFKNIGKEVY QVEVPSDVKV PVNWCKMSGT
910 920 930 940 950 960
KKTNRYYNDE LRKKIKKLLE AEELHLAIMS RMQEKFYIRF DSNYEQWLAL IKYTASIDCF
970 980 990 1000 1010 1020
FSLSQAAAAL GEPYCRPEII EQKDGHLYFE ELRHPCINAS AASTFVPNDV VLGGESPNMI
1030 1040 1050 1060 1070 1080
VLTGPNMAGK STLLRQVCIA VIMAQLGCWV PAKRASITPM TSIYTRLGAN DDIMSARSTF
1090 1100 1110 1120 1130 1140
MVELSETKKI LDECGPKSLV ILDELGRGTS TYDGHAIAYA VLHHLVSNIG CLGFFSTHYQ
1150 1160 1170 1180 1190 1200
SLCVDFMHHR QVRLMQMAAA VDEKIRRVTF LYKLEDGICP KSYGMNVASM AGLPEKVIDA
1210 1220 1230 1240 1250
AEEKASELEQ ASASFINASD DIALMSDFLQ VLRISKSIEP LTAVNIPLIL DSFE