O74476
Gene name |
sal3 |
Protein name |
Importin subunit beta-3 |
Names |
Importin beta sal3 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC1840.03 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O74476
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O74476-F1 | Predicted | AlphaFoldDB |
No variants for O74476
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O74476 | |||||
No associated diseases with O74476
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nuclear periphery | The portion of the nuclear lumen proximal to the inner nuclear membrane. |
| nuclear pore | A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| nuclear import signal receptor activity | Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein. |
| nuclear localization sequence binding | Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSGFPPEVL | SPLLNLVQGL | SSPDNTVRND | AEKSLSSDWI | SQRADLLLNG | LAILAYQSED |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PAVRSFCLVL | CRRISFRTLP | GDSELEVFSS | ISNESKQSLQ | SQLLACFVKE | SVPTVRNKLC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DTIAEIARSI | YDCQGEWPEL | INVIFNAVNS | PDESFRESVF | RTITSLPRLL | SGQDSAVTPL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FTTGLADPSI | RVRISAARAY | SAVILESKQS | TRDQVIPLLP | SLMNILPPLQ | QDRDSDNLAD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CLMAITEIAE | VFPKLFKPIF | ESVIAFGLGI | IKDKELDNSA | RQAALELLVC | FSEGAPAMCR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KSSDYTDQLV | LQCLLLMTDV | AGDPEDEAEE | LQEWLNTDDL | DQDESDANHV | VAEQAMDRLS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RKLGGKTILP | PSFTWLPRLI | PSQKWSERHA | ALMAISSIAE | GAEKLMKKEL | SRVLDMVLPL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LADPHPRVRW | AACNAVGQMS | TDFAPDMQVK | YPSRILEALV | PVLESPESRV | QAHAAAAMVN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FSEEADNKVL | EPYLDDILQR | LLTLLQSPKR | YVQEQAVTTI | ATVADAAAKK | FEKYFDAIMP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LLFNVLQQAD | GKEFRTLRGK | TMECATLIAL | AVGKQRFLPV | SQELIQILGN | IQMGITDSDD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PQASYLISAW | GRICRVLGSD | FVPFLSSVMP | PLLVAATSKP | DFTIIDDEVD | ESKYSEQDGW |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EFIPVHGQQV | GIRTSTLEDK | CTATEMLVCY | AAELKADFDP | YVNEVLTSVV | LPGLKFFFHD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GVRSACCKCI | PQLLNARILA | SNRDPAKVNE | LWEPILRKLL | DHIQNEPSVE | MLADYFECFY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QSLEISGLNL | SPSSMEALVA | AVDLQLKGFI | SRVQQREEEA | KNGDIDIEED | EDMILAVEND |
| 850 | 860 | 870 | 880 | 890 | 900 |
| QNLLNEINKT | FSVVLKIHKT | AFCPFWERLL | PYMDGFLSGN | DTVAKQWALC | MMDDLIEFTG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PDSWNYKDHF | LPYLAEGIQS | SEPEIRQAAS | YGIGVAAQHG | GELYAEICSS | ALPALFKMLE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LPDARDEEQI | YATENICVAI | CKICRFCSQR | VQDLDKVVTY | WINTLPVTHD | EDDAPYAYTF |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LAELMEQNHV | AVASQMPTII | TILAETFASG | VLRGRTLTRL | MEASKVYLAR | FPADQVNSVI |
| 1090 | |||||
| ATLSVDNQRA | LSAHF |