O74475

PR
Gene name
bgs4 (SPCC1840.02c)
Protein name
1,3-beta-glucan synthase component bgs4
Names
1,3-beta-D-glucan-UDP glucosyltransferase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC1840.02c
EC number
2.4.1.34: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

114-185 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O74475

Entry ID Method Resolution Chain Position Source
AF-O74475-F1 Predicted AlphaFoldDB

No variants for O74475

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O74475

No associated diseases with O74475

1 regional properties for O74475

Type Name Position InterPro Accession
domain 1,3-beta-glucan synthase component FKS1-like, domain-1 363 - 475 IPR026899

Functions

Description
EC Number 2.4.1.34 Hexosyltransferases
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Cell septum
  • Spore wall
  • Localizes to regions of active cell wall synthesis in an F-actin dependent manner
  • Following nuclear division and formation of the contractile ring, relocalizes from the cell ends to the assembling division septum
  • During sexual development, localizes to the mating projection, the contact region at the cell-cell fusion site, and to the forming spore walls
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

14 GO annotations of cellular component

Name Definition
1,3-beta-D-glucan synthase complex A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cell tip The region at the end of the longest axis of a cylindrical or elongated cell.
cleavage furrow The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
division septum A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mating projection tip The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
new growing cell tip A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plasma membrane of cell tip The portion of the plasma membrane surrounding the cell tip.
primary cell septum A cell septum that forms following nuclear division.
site of polarized growth Any part of a cell where non-isotropic growth takes place.

2 GO annotations of molecular function

Name Definition
1,3-beta-D-glucan synthase activity Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1).
glucosyltransferase activity Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

4 GO annotations of biological process

Name Definition
(1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds.
fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in fungal cell walls.
fungal-type cell wall polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall.
secondary cell septum biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGNNENVSG ITGHDAVSDD QYAYDSEVYD DQNAYQRQPA DAYSNEEFLD QADYDSMYGE
70 80 90 100 110 120
GYNGYDYPTG VTESYGDEYT PVDTASSGIN QYSTEKGKFT RPSDEYESEY SDYNAQPSDA
130 140 150 160 170 180
NNFYNLRGDG RYNAYDPSSD SLANVYNSVP YGSSPYDFSN SSFVGNSGSG TPLDGDSGSF
190 200 210 220 230 240
YADSANLTNR EPYPAWTPEN ELPLTKEEIE DIFIDLTNKL GFQRDSMRNM YDFFMCLLDS
250 260 270 280 290 300
RASRMTPDQA LLTLHADYIG SDIANYKKWY FASQMDREDA VGLANVGIYG GKVTSIKEKG
310 320 330 340 350 360
KFFSRNKKAP KVVKPPRKSR FKRKKKKEQP EEAEDEYIDV NTDDSLESAE YRWRSHMRSM
370 380 390 400 410 420
TQFERAQQIA LWLLLWGEAN NVRFMPEVIA FLFKCAYDYI ISPEAQNVTE PVPEGYYLDN
430 440 450 460 470 480
IVSPLYQYMH DQQFEIINGK YVRRERPHDQ LIGYDDINQL FWHAEGIARL IFEDGTRLID
490 500 510 520 530 540
IPASERFHRL PEVQWNRAFY KTYYESRSWF HLITNFNRIW VIHFGMFWYF TAFNSPTLYT
550 560 570 580 590 600
KPFHQRDGPK PTGASQWAAV ACTSVVSCII MAAASLCEYL FVPRRFPGSK PIWKRLCIIV
610 620 630 640 650 660
LIAIINLIPI VYIFGFSSKH QQRSGRRIAV GVVAFLMSIA TYVYFSLVPL QSTFGKLSVK
670 680 690 700 710 720
DSRKYLANKY FTSNFAPLKF DNQALSVIIW VCVFTCKFAE SYFFLTLSIR DPIIVLSTMR
730 740 750 760 770 780
PYLCSIYWAG SRLCFVQPRI ILGIMYFTDL ILFFLDTYLW YIIFNTIFSV LRSFVLGISI
790 800 810 820 830 840
LTPWRNIFSR MPQRIYGKIL ATNDMEIKYK PKILISQIWN AIVISMYREH LLSIDHVQRL
850 860 870 880 890 900
LYHQVPAEEG RRTLRTPTFF VSQDDNIVHT TFFPANSEAE RRLSFFAQSL ATPIPEPVPV
910 920 930 940 950 960
DNMPTFTVLI PHYAEKILLS LREIIREEDQ LSRVTLLEYL KQLHPVEWDC FVKDTKILVE
970 980 990 1000 1010 1020
ENAPYENDSV SEKEGTYKSK VDDLPFYCIG FKSAMPEYTL RTRIWASLRS QTLYRTISGF
1030 1040 1050 1060 1070 1080
MNYSRAIKLL YRVENPEIVQ MFGGNTDRLE RELDRMARRK FKLVVSMQRY AKFTKEEYEN
1090 1100 1110 1120 1130 1140
AEFLLRAYPD LQIAYLDEDP PEEEGAEPQL FAALIDGHSE IMENERRRPK YRIRLSGNPI
1150 1160 1170 1180 1190 1200
LGDGKSDNQN MSLPFYRGEY IQLIDANQDN YLEECLKIRS VLAEFEEMET DNVNPYSESA
1210 1220 1230 1240 1250 1260
RERNKHPVAI LGAREYIFSE NIGILGDVAA GKEQTFGTLF SRTLAQIGGK LHYGHPDFLN
1270 1280 1290 1300 1310 1320
GIFMTTRGGV SKAQKGLHVN EDIYAGMNAM LRGGRIKHCE YFQCGKGRDL GFGSILNFNT
1330 1340 1350 1360 1370 1380
KVGTGMGEQM LSREYYYLGT QLQLDRFLSF YFAHPGFHLN NMFIMLSVQL FMVVLINLGA
1390 1400 1410 1420 1430 1440
IYHVVTVCYY NGNQKLSYDT SIVPRGCYQL GPVLSWLKRC VISIFIVFWI SFIPLTVHEL
1450 1460 1470 1480 1490 1500
IERGVWRATK RFFKQIGSFS PLFEVFTCQV YSQAITSDLA YGGARYIGTG RGFATARLPF
1510 1520 1530 1540 1550 1560
SILYSRFAVP SIYIGARFLM MLLFGTMTVW VAHLIYWWVS IMALCVAPFL FNPHQFDWND
1570 1580 1590 1600 1610 1620
FFVDYREFIR WLSRGNSRSH ANSWIGYCRL TRTRITGYKR RVLGQPSDKI SMDTPRAKFT
1630 1640 1650 1660 1670 1680
NVFFSDVLIP ALLAAGAIIP YFFINSQPGN PMFITDPNNP SPYVHDTKTG TNPILRLVII
1690 1700 1710 1720 1730 1740
SLIPIAAGFG MSGFFGGMAC CLGPAFGLCC KKFPSIFAAI AHTIQIFIFI AIFEVCWFLD
1750 1760 1770 1780 1790 1800
GWSLPKTVLA FCAVTAIHRF IFKILTLLCL SREVKQDSAN ISWWSGKWYG KGYGYHAFTL
1810 1820 1830 1840 1850 1860
PAREFVCKAI ELNLFATDFF LGHLLLFFML PVICIPYIDR WHSVLLFWLR PSRQIRPPIF
1870 1880 1890 1900 1910 1920
STKQNRLRKR IVRRYSALYF SILVIFLILI IVPLAAGAEI RQGLTASEAV AKGAVGWNQT
1930 1940 1950
NSSIGSGIIQ PRDTNYTANY SFWYDRYHFE FNTTY