O74445

PR
Gene name
rpt4 (SPCC1682.16, SPCC306.01)
Protein name
Probable 26S proteasome subunit rpt4
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC1682.16
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O74445

Entry ID Method Resolution Chain Position Source
AF-O74445-F1 Predicted AlphaFoldDB

No variants for O74445

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O74445

No associated diseases with O74445

5 regional properties for O74445

Type Name Position InterPro Accession
domain AAA+ ATPase domain 165 - 304 IPR003593
domain ATPase, AAA-type, core 169 - 302 IPR003959
conserved_site ATPase, AAA-type, conserved site 272 - 290 IPR003960
domain Proteasomal ATPase OB C-terminal domain 56 - 111 IPR032501
domain AAA ATPase, AAA+ lid domain 325 - 366 IPR041569

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic proteasome complex A proteasome complex found in the cytosol of a cell.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
proteasome-activating activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

4 GO annotations of biological process

Name Definition
positive regulation of mitotic metaphase/anaphase transition Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
positive regulation of RNA polymerase II transcription preinitiation complex assembly Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSERDTALEK YKSYLLQHRE WDSKLKDLRF GNRDLVKKYD KTEDDIKSLQ SVGQIIGEVL
70 80 90 100 110 120
KQLDSERFIV KASSGPRYVV GCRNNVDQSH LVQGVRVSLD MTTLTIMRIL PREVDPLVYN
130 140 150 160 170 180
MSIEDPGDIS FAGVGGLNEQ IRELREVIEL PLKNPELFLR VGIKPPKGVL LYGPPGTGKT
190 200 210 220 230 240
LLARAVAASL GVNFLKVVSS AIVDKYIGES ARIIREMFGY AKEHEPCVIF MDEIDAIGGR
250 260 270 280 290 300
RFSEGTSADR EIQRTLMELL NQMDGFDYLG QTKIIMATNR PDTLDPALLR PGRLDRKIEI
310 320 330 340 350 360
PLPNEVGRME ILKIHLEKVS KQGEIDYEAL VKLTDGTNGA DLRNVVTEAG FIAIKEDRDY
370 380
VIQSDLMSAA RKVADLKKLE GTIDYQKL