O74444

PR
Gene name
mug122 (SPCC1682.15)
Protein name
Meiotically up-regulated gene 122 protein
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC1682.15
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

395-714 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O74444

Entry ID Method Resolution Chain Position Source
AF-O74444-F1 Predicted AlphaFoldDB

No variants for O74444

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O74444

No associated diseases with O74444

3 regional properties for O74444

Type Name Position InterPro Accession
domain Phox homology 344 - 416 IPR001683
domain Phox-associated domain 88 - 261 IPR003114
domain Sorting nexin, C-terminal 578 - 731 IPR013937

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

1 GO annotations of biological process

Name Definition
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYRKWDLCIT RHLLPYIEHS VIPIIALLVL SLIFYILYIC FGTTSYILSG IILGAYVNSL
70 80 90 100 110 120
FHNNHSVILN IKHPELGEPL KPYQTPLPPE LEAPLQLLIS KLTQHYINGW YKHVSEDPSF
130 140 150 160 170 180
IREVQSTIEY IMRQFYAYVS SQESSHIIYE LLKNAISTTT LVLSDLNHFR SKKIPLTEFA
190 200 210 220 230 240
LRYPESAVSK LLDQASIERT LRAQASAMIV KFSRPEDSAC LPLHCLLREV LAMQVFKRIT
250 260 270 280 290 300
THCSSPRFVN RCIILYFSSS EDKSDCLAKK NYVNKCLMAK ALKDYPVHTN IDPDAGKLSF
310 320 330 340 350 360
DDAFYEAHIE LHYQFLKEAS LNTLIKDKKM LKFIITVRPV HLHVSPWVVY RRYRGFKTLY
370 380 390 400 410 420
YLLKKQSARN GRAVPSFPVW RGNTYEKFRE GLYFFIEALL HDSHFATNVD VRKFFAKSMR
430 440 450 460 470 480
SHPLVDDIYN GFDVDKKHQS SSVPTLPNLT NISRVLSNKT SKSAKPKRSE RTGLLSHQST
490 500 510 520 530 540
LAPEPLSQQR DSFELCTTGY RDTGSCTSDD EDSIHEPYRP ASTQPTENPP AMPDHNGSPT
550 560 570 580 590 600
TEPPKPNAFE LKEERLKEII SGGFALVDEL CSLNSKLWFF RKSVLTIMKT TVLHGPGRFS
610 620 630 640 650 660
AQVERMLKNQ IYDKLSNTQL VGDLLTSLIL NVWPDEKKAM ESHSTRAHRR STESKISFDS
670 680 690 700 710 720
EADSLFEEAS KSVPEDPVSV FCDEESDESL RLRAEKTLVE NALSENFTLM LGQSTSEESL
730 740
KIIFELLQEP QFVQGFLAHL LSNALRSII