Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for O74435

Entry ID Method Resolution Chain Position Source
AF-O74435-F1 Predicted AlphaFoldDB

No variants for O74435

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O74435

No associated diseases with O74435

2 regional properties for O74435

Type Name Position InterPro Accession
domain AAA+ ATPase domain 51 - 207 IPR003593
domain Cdc6, C-terminal 294 - 382 IPR015163

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Associates with the half-bridge structure of the SPB
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
half bridge of mitotic spindle pole body Structure adjacent to the plaques of the mitotic spindle pole body.
half bridge of spindle pole body Structure adjacent to the plaques of the spindle pole body.
meiotic spindle pole body The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
mitotic spindle pole body The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.

5 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic spindle pole body duplication Any spindle pole body duplication that is involved in the mitotic cell cycle.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein localization to meiotic spindle pole body A process in which a protein is transported to, or maintained in, a location within a meiotic spindle pole body.
spindle pole body duplication Construction of a new spindle pole body.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFANARAKRR SRASSPTPAR LGGYAPLRVE ITEEQRQDIN EAFKLFDSDK DNAIDYHELR
70 80 90 100 110 120
AAMRALGFNA EKSEVLKILR DFDKTGKGYL QMEDFVRVMT EKIVERDPLE EIKRAFELFD
130 140 150 160 170
DDETGKISLR NLRRVAKELN ENIDDQELEA MIEEFDLDQD GEINEQEFIA IMMDEA