Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O74270
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O74270-F1 | Predicted | AlphaFoldDB |
No variants for O74270
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O74270 | |||||
No associated diseases with O74270
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNKLPKGWNF | TIVDDNADST | NSENIQGKRP | RRSRTSVQRS | DGASPIIRDN | IVLIRTDDNE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EFKVGDTIEI | TQGKGPEDPT | TEYGLITEIK | FGNSEFIEVI | VDWFIRSSEI | VGMPNDFFAD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NELLLTPFRS | EVKFIDFIRP | INVLSESQFA | DVVIDESNSH | STFLVKRATD | NEGNFSDIFD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YKDFSGKVLE | NPKKCAIQVK | ELISTTVQKE | LLKEFSKEQR | KKKANKVSTT | GRVTRFNKRK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ESVSTKAIKP | ENKQVKIEID | NDVLSDQSEE | KQEESDYNEA | EDANSALESD | EENISQESED |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SEVEYSTKKK | LKNKKLSRRS | KAAATPSPKR | KLQKKDIEDI | YSVVTPTKRM | KLGKDDRDSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PVFLSPTKSV | PSEFTDPKSV | AFKEVKQRLH | TSQKLNALPG | REDEFAMIYM | NHESAVNEKT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GCCVYVCGLP | GMGKTATIKD | VVEQMTYSSE | RGEMEQFSYL | ELNGLKLLSP | TVAYEALWHH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ISGDKVSASN | AALLLEEYFK | REDHKRKPLV | ILMDEFDQIA | TKKQNVMYNF | FNWPTYSTSK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LIVIAVANTM | DLPERMLTNK | IASRLGLRRI | QFRGYTFQQL | GDIITHRLEM | ITKNNRRKVV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ITSDAIGFAS | RKVASVSGDA | RRALTICRRA | VEIAEKEYLE | NKKGEDDSEP | YQVLISHIST |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AINETVNSPL | SKYIASLPFA | SKLVLASLLR | RSRRTGLAEN | SLGDIIDEMR | NSFAMATHSE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EQGSDELNMQ | DVLYSDKTFT | ATNETVPILN | LRIHFFKQIV | TSLVEAGIII | QQNSPGETSR |
| 790 | 800 | ||||
| LVKLDVPEEE | VVSVFKKDNA | ISQFL |