O74212

PR
Gene name
DES1
Protein name
Acyl-lipid (8-3)-desaturase
Names
Delta(5) fatty acid desaturase, Delta-5 fatty acid desaturase
Species
Mortierella alpina (Oleaginous fungus) (Mortierella renispora)
KEGG Pathway
EC number
1.14.19.30: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

54-143 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O74212

Entry ID Method Resolution Chain Position Source
AF-O74212-F1 Predicted AlphaFoldDB

5 variants for O74212

Variant ID(s) Position Change Description Diseaes Association Provenance
21 G>D strain: ATCC 32221 [UniProt] No
88 V>I strain: ATCC 32221 [UniProt] No
111 D>N strain: ATCC 32221 [UniProt] No
227 F>S strain: ATCC 32221 [UniProt] No
248 D>H strain: ATCC 32221 [UniProt] No

No associated diseases with O74212

3 regional properties for O74212

Type Name Position InterPro Accession
domain Cytochrome b5-like heme/steroid binding domain 6 - 82 IPR001199
domain Fatty acid desaturase domain 148 - 420 IPR005804
binding_site Cytochrome b5, heme-binding site 37 - 44 IPR018506

Functions

Description
EC Number 1.14.19.30 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
di-homo-gamma-linolenate delta5 desaturase activity Catalysis of the reaction: all-cis-icosa-8,11,14-trienoate + O2 + a reduced electron acceptor <=> arachidonate + 2 H2O + an oxidized electron acceptor.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGTDQGKTFT WEELAAHNTK GDLFLAIRGR VYDVTKFLSR HPGGVDTLLL GAGRDVTPVF
70 80 90 100 110 120
EMYHAFGAAD AIMKKYYVGT LVSNELPVFP EPTVFHKTIK TRVEGYFTDR DIDPKNRPEI
130 140 150 160 170 180
WGRYALIFGS LIASYYAQLF VPFVVERTWL QVVFAIIMGF ACAQVGLNPL HDASHFSVTH
190 200 210 220 230 240
NPTVWKILGA THDFFNGASY LVWMYQHMLG HHPYTNIAGA DPDVSTFEPD VRRIKPNQKW
250 260 270 280 290 300
FVNHINQDMF VPFLYGLLAF KVRIQDINIL YFVKTNDAIR VNPISTWHTV MFWGGKAFFV
310 320 330 340 350 360
WYRLIVPLQY LPLGKVLLLF TVADMVSSYW LALTFQANHV VEEVQWPLPD ENGIIQKDWA
370 380 390 400 410 420
AMQVETTQDY AHDSHLWTSI TGSLNYQAVH HLFPNVSQHH YPDILAIIKN TCSEYKVPYL
430 440
VKDTFWQAFA SHLEHLRVLG LRPKEE