O74165
Gene name |
ERG9 |
Protein name |
Squalene synthase |
Names |
SQS, SS, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase |
Species |
Cyberlindnera jadinii (Torula yeast) (Pichia jadinii) |
KEGG Pathway |
|
EC number |
2.5.1.21: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O74165
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O74165-F1 | Predicted | AlphaFoldDB |
No variants for O74165
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O74165 | |||||
No associated diseases with O74165
3 regional properties for O74165
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Squalene/phytoene synthase, conserved site | 178 - 193 | IPR019845-1 |
| conserved_site | Squalene/phytoene synthase, conserved site | 214 - 239 | IPR019845-2 |
| domain | Trans-isoprenyl diphosphate synthases, head-to-head | 41 - 328 | IPR033904 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.21 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| farnesyl-diphosphate farnesyltransferase activity | Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate. |
| squalene synthase activity | Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| isoprenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. |
| sterol biosynthetic process | The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKLLQLALH | PDELASIVQF | KLFRKNENAR | NPATESAELI | RCYELLNLTS | RSFAAVIEEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HPELRNVIMV | FYLVLRALDT | VEVDMSIENS | VKLPVLRQFH | EKLDTKDWTF | DGNSPNEKDR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CVLVEFDRIL | GQYHELKPQY | QKVIKEITEK | MGNGMADYIE | NENFNSNGLL | TIEDYDLYCY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YVAGLVGDGL | TQLIVLAKFG | NSELSVNKQL | FKSMGLFLQK | TNIIRDYEED | QVDGRAFWPK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EIWGKYANEL | SDFMKPENQS | QGLWCISELV | CNALDHVIDV | LQYLALVEEQ | TSFNFCAIPQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VMAIATLELV | FQNPQVLTQH | VKIRKGTTVS | LILESRTLEG | CARIFRRYLR | KIHHKSHPSD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PNYLRLGITI | GKIEQFLDGM | YPHYVPKGIT | PQTTSIRTQV | VKRLQLDEPM | KRDIDEEILK |
| 430 | 440 | ||||
| TRILLLSLGV | AVFGVVYGVV | RII |