O73932

PR
Gene name
igf2bp3-a (vera-a, vickz3-a)
Protein name
Insulin-like growth factor 2 mRNA-binding protein 3-A
Names
IGF2 mRNA-binding protein 3-A, IMP-3-A, 69 kDa RNA-binding protein A, IGF-II mRNA-binding protein 3-A, KH domain-containing transcription factor B3-A, RNA-binding protein Vera-A, Trans-acting factor B3-A, VICKZ family member 3-A, VLE-binding protein A, Vg1 RNA-binding protein A, Vg1 RBP-A, Vg1 localization element binding protein A, VgLE-binding and ER association protein A
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:394293
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

128-236 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O73932

Entry ID Method Resolution Chain Position Source
AF-O73932-F1 Predicted AlphaFoldDB

No variants for O73932

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O73932

No associated diseases with O73932

10 regional properties for O73932

Type Name Position InterPro Accession
domain RNA recognition motif domain 2 - 75 IPR000504-1
domain RNA recognition motif domain 81 - 156 IPR000504-2
domain K Homology domain 204 - 275 IPR004087-1
domain K Homology domain 285 - 358 IPR004087-2
domain K Homology domain 417 - 488 IPR004087-3
domain K Homology domain 499 - 571 IPR004087-4
domain K Homology domain, type 1 208 - 272 IPR004088-1
domain K Homology domain, type 1 290 - 354 IPR004088-2
domain K Homology domain, type 1 421 - 484 IPR004088-3
domain K Homology domain, type 1 503 - 568 IPR004088-4

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Endoplasmic reticulum
  • Accumulates along the vegetal cortex in oocytes as oogenesis progresses ('late pathway' for RNA localization)
  • Colocalizes with Vg1 RNA along the vegetal cortex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule.

2 GO annotations of biological process

Name Definition
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNKLYIGNLS ENVSPTDLES LFKESKIPFT GQFLVKSGYA FVDCPDETWA MKAIDTLSGK
70 80 90 100 110 120
VELHGKVIEV EHSVPKRQRS RKLQIRNIPP HLQWEVLDSL LAQYGTVENC EQVNTESETA
130 140 150 160 170 180
VVNVTYANKE HARQGLEKLN GYQLENYSLK VTYIPDEMAT PQAPSQQLQQ QPQQQHPQGR
190 200 210 220 230 240
RGFGQRGPAR QGSPGAAARP KPQTEVPLRM LVPTQFVGAI IGKEGATIRN ITKQTQSKID
250 260 270 280 290 300
IHRKENAGAA EKPITIHSTP EGCSAACKII MEIMQKEAQD TKFTEEIPLK ILAHNNFVGR
310 320 330 340 350 360
LIGKEGRNLK KIEQDTDTKI TISPLQDLTL YNPERTITVK GSIEPCAKAE EEIMKKIRES
370 380 390 400 410 420
YENDIAAMNL QAHLIPGLNL NALGLFPSSS SGMPPPSVGV PSPTSSTSYP PFGQQPESET
430 440 450 460 470 480
VHLFIPALAV GAIIGKQGQH IKQLSRFAGA SIKIAPAEGP DAKLRMVIIT GPPEAQFKAQ
490 500 510 520 530 540
GRIYGKLKEE NFFGPKEEVK LETHIKVPSY AAGRVIGKGG KTVNELQNLT SAEVVVPRDQ
550 560 570 580 590
TPDENDEVVV KITGHFYASQ LAQRKIQEIL AQVRRQQQQQ QKTVQSGQPQ PRRK