O73853
Gene name |
cyp17a1 (cyp17) |
Protein name |
Steroid 17-alpha-hydroxylase/17,20 lyase |
Names |
17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17 |
Species |
Ictalurus punctatus (Channel catfish) (Silurus punctatus) |
KEGG Pathway |
ipu:100313515 |
EC number |
1.14.14.19: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O73853
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O73853-F1 | Predicted | AlphaFoldDB |
No variants for O73853
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O73853 | |||||
No associated diseases with O73853
1 regional properties for O73853
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 438 - 447 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.19 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 17-alpha-hydroxyprogesterone aldolase activity | Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione. |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| steroid 17-alpha-monooxygenase activity | Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| sex differentiation | The establishment of the sex of an organism by physical differentiation. |
| steroid biosynthetic process | The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGWLICFCVF | AAIIIVALYL | RKIHGFLVDD | RAPPNLPSLP | IIGSLLSINS | NSPPHIFFQQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LQKKYGDIYS | LDMGSNRVII | VNNHHHAKEV | LLRKGKIFAG | RPRTVTTDIL | TRDGKDIAFG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DYSATWKFHR | KIVHGALCMF | GEGTASIEKI | ICREASSMCE | ILTNLQSSAA | DLAPELTRAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TNVVCTLCFS | SSYKRGDPEF | EAMLKYSQGI | VDTVAKDSLV | DIFPWLQLFP | NEDLRILRRC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VSIRDKLLQK | KYEEHKADFS | DNIQRDLFDA | LLRAKNSSEN | NNTSTQDVGL | TDDHLLMTVG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DIFGAGVETT | TTVLKWSILY | LIHHPQVQRK | IQEELDAKIG | RDRHPQVNDR | GNLPYLEATI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| REVLRIRPVS | PLLIPHVALS | DANIGEYTVQ | KGTRVIVNLW | SLHHDEKEWK | NPELFNPERF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LNEEGNSLCC | PSLSYLPFGA | GVRVCLGEAL | AKLELFLFLS | WILQRFTLEV | PGGQPLPELQ |
| 490 | 500 | 510 | |||
| GKFRVVLQPQ | KYKVIARLRT | GWEKSLQSQE | SESG |