O70695

PR
Gene name
Segment-1
Protein name
RNA-directed RNA polymerase
Names
VP1
Species
African horse sickness virus 9 (AHSV-9)
KEGG Pathway
vg:2943147
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

13-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for O70695

Entry ID Method Resolution Chain Position Source

No variants for O70695

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O70695

No associated diseases with O70695

1 regional properties for O70695

Type Name Position InterPro Accession
domain RNA-directed RNA polymerase, reovirus 563 - 814 IPR007097

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

2 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
viral genome replication Any process involved directly in viral genome replication, including viral nucleotide metabolism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVITVQGADL VRRALNRLFK YGRIDGTKMY YEYYRYSSKM RETRRKKGTK YKTDDEFLER
70 80 90 100 110 120
ERDAGRLKLY DLQVIREASW EDLLYENVHT AELDIYVRSI LKLEDLEPEE EFLRNYAVYD
130 140 150 160 170 180
GVHPLKDFVE MRAKNEMQIF GDMPIKAWIS VLMEISRETK HKPLGLMVAS DFVGRFGSPF
190 200 210 220 230 240
EQNFRDLSQI NEYGYCYSSP LLFEMCVTES ILEFNMWYRM REERIQSLKF GLEVIDPFKL
250 260 270 280 290 300
IREFFEICLP HPKKINNTLR SPYSWFVKNW GIGCSRVKVL TSIGGEDRNS KEVFYTGYHE
310 320 330 340 350 360
TENLYSEIVL KSKFYRESLK QNMTKTEEAI TYSQKLGNHG RTMPIFLKML KAVYTTEFDP
370 380 390 400 410 420
TKISHVILAS LCLSIQTITG YGRAWVVNKS SDLEAQMKPS SDNYVQRVCD YTKNNFIKAY
430 440 450 460 470 480
EEARRGGEEI VMPEDMYTSI LRLAKNTSSG FSTSIDVFKR YGPNAKGGRG EKIQITSRIK
490 500 510 520 530 540
ALVIFTKGHE IFTPKNLALK YNTTEFFQTK GSRDVPIKST RIVYSINLSI LVPQLIVTLP
550 560 570 580 590 600
LNEYFARAGG STLPETQRMG GKIIVGDLEA TGSRVMDAAD TFRNSSDPLN LTIAIDYSEF
610 620 630 640 650 660
DTHLTPYNFR NGMLDGIREA MRRYQHLRYE GYTLDELIEF GYGEGRVMNT LWNGKRRVFK
670 680 690 700 710 720
VAFEDYVMLS DEDKVQGTFK PPIGVKPVKN IKICEELEKK ADGRDLILVS PTDGSDLALI
730 740 750 760 770 780
NTHLSGENST LIANSLHNLA IGTVIREEVK RIFGDDISFK SEQYVGDDTL FYTELRTRSV
790 800 810 820 830 840
ERFDSIVDTI FEVIKKSGHE ASMSKTLIAP FSVEKTQTHA KQGIYIPQDR MMLVSSERRK
850 860 870 880 890 900
DIEDVAGYLR SQVQTLTTKI SRGFSHELAQ IIFMMKSSII GHRKLKRTIK DGGYRDRKYD
910 920 930 940 950 960
DDKEDGFTLI MLRDPLIAFY PVEWNGFGAH PAAMNIIMTE DMFVDSVMRG ECRAWMEPLV
970 980 990 1000 1010 1020
KLIDQSPPLW NETSADKRMI GTDSTMSFFS RMARPAVRTV LTNSEVGDAV RSLPLGDFSP
1030 1040 1050 1060 1070 1080
FNISKTMMHS ALLKEKNARS LLTPAYEMEY QKELQGWRPR QKKFLVTSNE MEITTNYMKM
1090 1100 1110 1120 1130 1140
FNVGKIPLHG LALKFFPDVN LSKEFFLQKS VLGNRESPRA RMSYVDRIDS ILRGDVVMRG
1150 1160 1170 1180 1190 1200
FITANTIINI LEKLGHTHSA SDLTTLFEIM NLSSSVAQRL SEYITTERVR FDAMKLSKRG
1210 1220 1230 1240 1250 1260
ICGDEFSMSL DVCTQTMVDR YIRAPTQFTK TELDAVNLYV AQHIMLDAAT GLTPSRYDIN
1270 1280 1290 1300
VSGDERVRFK QRVARFNTHL PKMRMVKRLI ETERLSARLV QNQFV