O70472

PR
Gene name
Tmem131 (D1Bwg0491e, Kiaa0257, Rw1)
Protein name
Transmembrane protein 131
Names
Protein RW1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:56030
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1512-1586 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O70472

Entry ID Method Resolution Chain Position Source
AF-O70472-F1 Predicted AlphaFoldDB

107 variants for O70472

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389857106 47 V>W No EVA
rs3388463473 65 S>W No EVA
rs3388463893 70 E>D No EVA
rs32871218 89 G>S No EVA
rs3388465993 116 H>Y No EVA
rs3389856066 198 Q>L No EVA
rs3388464540 228 I>V No EVA
rs3388463478 232 N>K No EVA
rs3388464126 262 T>I No EVA
rs3388463742 262 T>S No EVA
rs3388464674 274 K>N No EVA
rs3388465650 282 S>P No EVA
rs3388464049 349 G>A No EVA
rs3388463561 378 A>T No EVA
rs3388463716 378 A>V No EVA
rs3388465664 398 K>E No EVA
rs3388464328 403 S>F No EVA
rs3388464669 414 S>I No EVA
rs3388463397 417 K>* No EVA
rs3388464108 430 Y>* No EVA
rs3388463871 430 Y>D No EVA
rs3388463516 431 L>* No EVA
rs3388464265 438 T>A No EVA
rs3388465652 478 M>K No EVA
rs231021711 486 Q>K No EVA
rs3388464192 495 S>L No EVA
rs3388464071 535 F>L No EVA
rs3388464285 579 S>N No EVA
rs3388466054 618 S>F No EVA
rs3388463558 621 T>S No EVA
rs211720144 626 H>Y No EVA
rs3388466068 653 Y>N No EVA
rs3388464839 691 L>* No EVA
rs3388465609 700 K>R No EVA
rs3388465686 718 K>R No EVA
rs3388463828 721 R>W No EVA
rs3388465657 735 I>F No EVA
rs3388466026 786 F>V No EVA
rs3388463548 795 N>S No EVA
rs3388463491 814 I>V No EVA
rs32861748 815 V>I No EVA
rs241899807 827 V>I No EVA
rs3388463700 867 A>T No EVA
rs3388463383 869 Y>F No EVA
rs3388464224 878 K>N No EVA
rs3388464610 892 D>H No EVA
rs3388465987 902 R>T No EVA
rs3388465653 905 A>D No EVA
rs3388464114 921 H>Y No EVA
rs3388464450 922 F>I No EVA
rs212638320 943 L>H No EVA
rs3388464110 996 L>M No EVA
rs213313093 1016 T>A No EVA
rs213313093 1016 T>P No EVA
rs3388464711 1055 S>T No EVA
rs3388463505 1066 F>S No EVA
rs3388463878 1093 L>S No EVA
rs3388464856 1112 P>S No EVA
rs3389847337 1114 W>* No EVA
rs3389862861 1115 E>V No EVA
rs3389847944 1117 A>V No EVA
rs3389835109 1118 L>R No EVA
rs3389864905 1118 L>V No EVA
rs3388464569 1201 R>W No EVA
rs3388464124 1219 S>R No EVA
rs233697187 1231 V>I No EVA
rs32864420 1263 T>P No EVA
rs236365911 1277 R>K No EVA
rs3388463547 1277 R>SE* No EVA
rs3388463664 1298 Q>* No EVA
rs217654368 1312 P>L No EVA
rs243142575 1320 A>T No EVA
rs258563958 1341 S>T No EVA
rs3388463974 1352 K>T No EVA
rs3388464278 1355 D>Y No EVA
rs3388464236 1358 D>E No EVA
rs3388463681 1360 S>F No EVA
rs3388464175 1376 S>G No EVA
rs32865100 1391 P>L No EVA
rs3388464836 1396 E>V No EVA
rs3388466079 1397 K>S No EVA
rs3388464837 1399 K>* No EVA
rs3389847458 1443 K>* No EVA
rs238357281 1479 G>D No EVA
rs32861819 1492 N>K No EVA
rs3388464188 1493 K>* No EVA
rs3388463723 1501 K>Q No EVA
rs3388464208 1507 T>I No EVA
rs3388464832 1511 G>E No EVA
rs3388465660 1518 P>L No EVA
rs3388466012 1569 P>T No EVA
rs3388464329 1576 L>F No EVA
rs3388463983 1591 K>I No EVA
rs226971218 1603 S>P No EVA
rs3388463612 1620 V>I No EVA
rs3388463858 1623 S>I No EVA
rs3388464461 1638 S>R No EVA
rs3388464323 1656 A>T No EVA
rs32856874 1742 S>G No EVA
rs3388463725 1743 Q>* No EVA
rs3388464054 1768 S>C No EVA
rs3388466006 1780 H>Y No EVA
rs264525099 1788 N>D No EVA
rs3388463443 1790 S>I No EVA
rs219075827 1817 T>A No EVA
rs32862006 1827 G>S No EVA
rs222654424 1839 A>T No EVA

No associated diseases with O70472

1 regional properties for O70472

Type Name Position InterPro Accession
domain Cation/H+ exchanger 28 - 412 IPR006153

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9V7H4 CG8370 Transmembrane protein 131 homolog Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MGKRAGGAAA AAAAASTSSA AGLEPAAGRG GGPRSAAAGL LGALHLVMTL VVAAARAEKE
70 80 90 100 110 120
AFIQSESIIE VLRFDDGGLL QTETTLGLGS YQQKSISLYR GNCRPIRFEP PMLDFHEQPV
130 140 150 160 170 180
GMPKMEKVYL HNPSSEETIT LVSISATTSH FHASFFQNRK ILPGGNTSFD VVFLARVVGN
190 200 210 220 230 240
VENTLFINTS NHGVFTYQVF GVGVPNPYRL RPFLGARVPV NSSFSPIINI HNPHSEPLQV
250 260 270 280 290 300
VEMYSSGGDL HLELPTGQQG GTRKLWEIPP YETKGVMRAS FSSREADNHT AFIRIKTNAS
310 320 330 340 350 360
DSTEFIILPV EVEVTTAPGI YSSTEMLDFG TLRTQDLPKV LNLHLLNSGT KDVPITSVRP
370 380 390 400 410 420
TPQNDAITVH FKPVTLKASE SKYTKVASIS FDASRAKKPS QFSGKITVKA KEKSYSKLEI
430 440 450 460 470 480
PYQAEVLDGY LGFDHAATLF HIQDSPADPV ERPIYLTNTF SFAILIHDVL LPEEARIMFQ
490 500 510 520 530 540
VHNFSQPVLI LPNESGYIFT LFFMPSTSSM HIDNNILLVT NASKFHLPVR VYTGFLDYFV
550 560 570 580 590 600
LPPKIEERFI DFGVLSATEA SSILFAIINS NPIELAIKSW HIIGDGLSIE LVATERGNRS
610 620 630 640 650 660
TVIASLPELE RSSLPDQSPV TLASGHFAVF RVKLTAKKLE GVHDGAIQIT TDYEILTIPV
670 680 690 700 710 720
KAVIAVGSLT CFPKHMVLPP SFPGKIVHQS LNIMNSFSQK VKIQQIRSLS EDVRFYYKRL
730 740 750 760 770 780
RGNREDLEPG KKSKIANIYF DPGLQCGDHC YIGLPFLSKS EPKVQPGVAM QEDLWDADWD
790 800 810 820 830 840
AHQSLFKAWM GIKENAGHRL NAMFEVNTDL QKNIVSKVSA ELSWPSVLSS PRLLKFPLTN
850 860 870 880 890 900
TNCSSEEEIS LENPADVPVY VQFIPLALYS NPSVFADKLV SRFNLSKVAK LDLRTLEFQV
910 920 930 940 950 960
YRNSAHPLQS PTGFTEGLSR HFILNLILKP GEKKSVKVKF TPLHNRTVSS LIIVRNNLTV
970 980 990 1000 1010 1020
MDAVMVQGQG TTENLRVAGK LPGPGSSLRF KITEALLKDC IDRLKLREPN FTLKRTFKVE
1030 1040 1050 1060 1070 1080
NTGQLEIRVE TIEISGYACE GYGFKVVNCQ EFALSANASR DIVILFTPDF TASRVIRELK
1090 1100 1110 1120 1130 1140
FVTSSGSEFV FVLNASLPYH MLAACAEALP RPNWELALYI IISGVMSALF LLVIGTAYLE
1150 1160 1170 1180 1190 1200
AQGIWEPFRR RLSFEASNPP FDVGRPFDLR RIVGISSEGN LNTLGCEHSH GRGFYSNASS
1210 1220 1230 1240 1250 1260
RPGTGSHRQC GTSVHPHSSH GSKNSADVDN VRTRNSSSMS SRTSPQAAAS QSTSKTSPLV
1270 1280 1290 1300 1310 1320
SETAAATQGH TASRKSRGAK QGQHSSQHHS HSHSPLEQHS QPPPPVPQHQ EPPPERLSPA
1330 1340 1350 1360 1370 1380
PLTHPSHPER ASTTRHSSED SDITSLIEAM DKDFDHHDSS PLDVFTEQPP SPMSKSKGKG
1390 1400 1410 1420 1430 1440
KSLQQRKAKP PKKQEEKEKR GKGKPQEDEL KDALADDDSS STTTETSNPD TEPLLREDTE
1450 1460 1470 1480 1490 1500
KHKGRPAVPE KQESELSQGK PKSKKLLNAK KEIPTDVKGS SFELPYTPSL ENKQRRNLPT
1510 1520 1530 1540 1550 1560
KIPLPTTLAS GSKSRNPPKT KGTNKLVENR PVALSKFLPS SQELGNTSSS EGEKDSPPPE
1570 1580 1590 1600 1610 1620
WDAVPVHKPS SSTDSLYKLS LQTLNADIFL KQRQTSPTPA SPSLPTAPCP FTSRGSYSSV
1630 1640 1650 1660 1670 1680
VNSSGSDTKA KQTSSSKSKL TKAASLPGKN GNPTFAAVAA GYDKSPGGNG FAKISSNKSD
1690 1700 1710 1720 1730 1740
FSSSLGISHI PVDSDGSDSS GLWSPVSNPN SPDFTPLNSF SAFGNSFNLT GAVFSKLSRS
1750 1760 1770 1780 1790 1800
CSQSSQRSWN EFNSGPSYLW DSPATDPSPS WPASSSSPTH TATSILGNSS GLWSTTPFSS
1810 1820 1830 1840 1850 1860
SIWSSNINSN LPFSTPTNAL SSISLMGTEN SAAAHTPSAS GPADDLGQTY NPWRIWSPTV
1870
GRRSSDPWSN SHFPHEN