O69761

PR
Gene name
msrA
Protein name
Peptide methionine sulfoxide reductase MsrA
Names
Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase
Species
Pseudomonas fluorescens
KEGG Pathway
EC number
1.8.4.11: With a disulfide as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

159-209 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O69761

Entry ID Method Resolution Chain Position Source
AF-O69761-F1 Predicted AlphaFoldDB

No variants for O69761

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O69761

No associated diseases with O69761

1 regional properties for O69761

Type Name Position InterPro Accession
domain Peptide methionine sulphoxide reductase MsrA domain 5 - 160 IPR002569

Functions

Description
EC Number 1.8.4.11 With a disulfide as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
L-methionine:thioredoxin-disulfide S-oxidoreductase activity Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
peptide-methionine (S)-S-oxide reductase activity Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTRHTETAIL AGGCFWGMQD LLRRYPGVLH TRVGYTGGDV PNATYRNHGN HAEAIEIVFD
70 80 90 100 110 120
PAVISYRQIL EFFFQIHDPS TPNRQGNDLG PSYRSAIYYL NEQQRDIAED TAADVDASHL
130 140 150 160 170 180
WPGRVVTEIE PAGPFWEAEP EHQDYLERIP NGYTCHFIRR MEAPQARLKV EFVRRRGDRF
190 200
RPFSALTTGG NQPGARGGLT NNTCQHPRH