O69531

PR
Gene name
folE (ML0223, MLCB2548.08c)
Protein name
GTP cyclohydrolase 1
Names
GTP cyclohydrolase I, GTP-CH-I
Species
Mycobacterium leprae (strain TN)
KEGG Pathway
mle:ML0223
EC number
3.5.4.16: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O69531

Entry ID Method Resolution Chain Position Source
AF-O69531-F1 Predicted AlphaFoldDB

No variants for O69531

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O69531

No associated diseases with O69531

3 regional properties for O69531

Type Name Position InterPro Accession
conserved_site GTP cyclohydrolase I, conserved site 98 - 114 IPR018234-1
conserved_site GTP cyclohydrolase I, conserved site 146 - 156 IPR018234-2
domain GTP cyclohydrolase I domain 41 - 218 IPR020602

Functions

Description
EC Number 3.5.4.16 In cyclic amidines
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTP cyclohydrolase I activity Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
7,8-dihydroneopterin 3'-triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALLDLGLES TAVPRIRVFD QQRAEAAIRE LLYAIGEDPD REGLADTPAR VARACRELFS
70 80 90 100 110 120
GLYTDPQTVL NTMFDEEHNE LVIVKEIPMY STCEHHLVSF HGVAHIGYLP GADGRVTGLS
130 140 150 160 170 180
KIARLVDLYA KRPQVQERLT SQIADALVSK LDPRGVIIVV EAEHLCMAMR GVRKPGAITT
190 200
TSAVRGQFKT DAASRAEALG LILRK