O69077
Gene name |
lysC (PA0904) |
Protein name |
Aspartokinase |
Names |
Aspartate kinase |
Species |
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
KEGG Pathway |
pae:PA0904 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O69077
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5YEI | X-ray | 230 A | PDB | ||
| AF-O69077-F1 | Predicted | AlphaFoldDB |
No variants for O69077
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O69077 | |||||
No associated diseases with O69077
7 regional properties for O69077
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aspartate/glutamate/uridylate kinase | 3 - 229 | IPR001048 |
| domain | Aspartate kinase | 63 - 403 | IPR001341 |
| domain | ACT domain | 266 - 340 | IPR002912-1 |
| domain | ACT domain | 346 - 412 | IPR002912-2 |
| conserved_site | Aspartate kinase, conserved site | 5 - 13 | IPR018042 |
| domain | CASTOR, ACT domain | 339 - 399 | IPR027795 |
| domain | Aspartokinase catalytic domain | 3 - 241 | IPR041740 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartate kinase activity | Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| diaminopimelate biosynthetic process | The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. |
| homoserine biosynthetic process | The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid. |
| lysine biosynthetic process via diaminopimelate | The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| threonine biosynthetic process | The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALIVQKFGG | TSVGTVERIE | QVAEKVKKFR | EAGDDVVVVV | SAMSGETNRL | IGLANQIMEQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PVPRELDVMV | STGEQVTIAL | LSMALIKRGV | PAVSYTGNQV | RILTDSAHTK | ARILHIDDTH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IRADLKAGRV | VVVAGFQGVD | GNGNITTLGR | GGSDTTGVAL | AAALKADECQ | IYTDVDGVYT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TDPRVVPQAR | RLDKITFEEM | LEMASLGSKV | LQIRAVEFAG | KYNVPLRVLH | SFQEGPGTLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TIDDEEESME | QPIISGIAFN | RDEAKLTIRG | VPDTPGVAFK | ILGPISAANV | EVDMIVQNVA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HDNTTDFTFT | VHRNDYLNAL | EILKQTAANI | GAREAIGDTN | IAKVSIVGVG | MRSHAGVASR |
| 370 | 380 | 390 | 400 | 410 | |
| MFEALAKESI | NIQMISTSEI | KVSVVIEEKY | LELAVRALHT | AFELDAPARQ | GE |