O68814

PR
Gene name
trpC1 (trpC, SCO2039, SC4G6.08c)
Protein name
Indole-3-glycerol phosphate synthase 1
Names
IGPS 1
Species
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
KEGG Pathway
sco:SCO2039
EC number
4.1.1.48: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O68814

Entry ID Method Resolution Chain Position Source
AF-O68814-F1 Predicted AlphaFoldDB

No variants for O68814

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O68814

No associated diseases with O68814

2 regional properties for O68814

Type Name Position InterPro Accession
conserved_site Indole-3-glycerol phosphate synthase, conserved site 51 - 68 IPR001468
domain Indole-3-glycerol phosphate synthase domain 2 - 257 IPR013798

Functions

Description
EC Number 4.1.1.48 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
indole-3-glycerol-phosphate synthase activity Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O.
phosphoribosylanthranilate isomerase activity Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

1 GO annotations of biological process

Name Definition
tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSVLDEIIDG VRADLAERQA RVSLDELKER AAKARPAKDG VAALRGDGVK VICEVKRSSP
70 80 90 100 110 120
SKGALAAIAD PAGLAADYEA GGAAVISVLT EERRFGGSLA DLDSVRARVD IPVLRKDFIV
130 140 150 160 170 180
TSYQLWEARA HGADLVLLIV AALEQPALES LIERAESIGL TPLVEVHDED EVERAVDAGA
190 200 210 220 230 240
KVIGVNARNL KTLEVDRGTF ERVAPEIPAH IVKVAESGVR GPHDLIAYAN EGADAVLVGE
250 260
SLVTGRDPKT AVSDLVAAGE HPALRHGRS