O67886
Gene name |
hemN (aq_2124) |
Protein name |
Oxygen-independent coproporphyrinogen III oxidase |
Names |
CPO, Coproporphyrinogen III dehydrogenase, CPDH |
Species |
Aquifex aeolicus (strain VF5) |
KEGG Pathway |
aae:aq_2124 |
EC number |
1.3.98.3: With other, known, acceptors |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O67886
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O67886-F1 | Predicted | AlphaFoldDB |
No variants for O67886
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O67886 | |||||
No associated diseases with O67886
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.98.3 | With other, known, acceptors |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| coproporphyrinogen dehydrogenase activity | Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine. |
| coproporphyrinogen oxidase activity | Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| porphyrin-containing compound biosynthetic process | The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. |
| protoporphyrinogen IX biosynthetic process | The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKAEFDKELI | KKYDRPGPRY | TSYPPATEFT | EEVKEDEYVK | RLIKSNERKT | PLSLYFHIPF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CEQRCLYCGC | NVIISHRKGI | EEPYLERVCR | EMDLVSQYLD | KDRKVIQLHW | GGGTPNYLSP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EQIKWFMEEI | RKRFEFGDNA | EISIELDPRY | LTDEQIKAIK | DAGFNRISLG | VQDLDPKVQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVNRVQPYEL | IKEKMEKLRE | AGFESINLDL | IYGLPYQTKE | SFEKTVEKVI | ELNPDRIATY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SFAYIPQVKP | HQQLLPKEAL | PSAEEKLRIF | EMVINKFQEA | GYVYIGMDHF | AKPEDELAVA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QRKGELWRNF | QGYTTKKGVE | LLGFGATSIG | MLYDSYFQNW | KTLRDYNKTV | DEGKIPVFRG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YVLNEDDFIR | REVIMDIMCN | LGVEFSKIEN | MFGINFREYF | AKELEELKEM | EEDGLIKVEE |
| 430 | 440 | 450 | |||
| DRIKIMPVGR | LLIRNVAMVF | DAHLRRKKEL | NFSRTI |