O67862
Gene name |
leuA (aq_2090) |
Protein name |
2-isopropylmalate synthase |
Names |
Alpha-IPM synthase, Alpha-isopropylmalate synthase |
Species |
Aquifex aeolicus (strain VF5) |
KEGG Pathway |
aae:aq_2090 |
EC number |
2.3.3.13: Acyl groups converted into alkyl groups on transfer |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O67862
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O67862-F1 | Predicted | AlphaFoldDB |
No variants for O67862
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O67862 | |||||
No associated diseases with O67862
4 regional properties for O67862
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pyruvate carboxyltransferase | 4 - 273 | IPR000891 |
| conserved_site | Alpha-isopropylmalate/homocitrate synthase, conserved site | 12 - 28 | IPR002034-1 |
| conserved_site | Alpha-isopropylmalate/homocitrate synthase, conserved site | 199 - 212 | IPR002034-2 |
| domain | 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 370 - 502 | IPR013709 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.3.13 | Acyl groups converted into alkyl groups on transfer |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2-isopropylmalate synthase activity | Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| leucine biosynthetic process | The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGEKVYIFDT | TLRDGEQAPG | FSMTTEEKLQ | MAHQLAKLNV | DIIEAGFAAA | SKGDFEAVNR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IAKEVKGPVI | CSLARALESD | IEIAAKALEP | AERKRIHTFI | ATSPIHMEYK | LRMTPDQVLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RIKKAVSFAR | NFTDDVEFSC | EDATRSEREF | LYRAIETAIK | HGATVINIPD | TVGYAIPEEF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GQLIEDIMNN | VPNIDKVILS | VHCHDDLGLA | TANSLTAVKH | GARQVECTIN | GIGERAGNAA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LEEVVMALKV | RKDFFGDLYT | DVNTKEIYKT | SRLLCRITGN | FVQPNKAIVG | DNAFAHESGI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HQHGVLSHRM | TYEIMNPEDV | GFPMSRIVLG | KHSGRHALKR | RLEELGFKFT | KEELDRIFEK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FKELADRKKE | VYDEDLEALI | YQEFMKIEDH | EPVKVLHFQV | QSGDNMIPTA | TVKLEFKGEE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| REASSTGNGP | VDATIKAIQK | ALGIEPKLLD | YSIKALTPNT | DAQAEARVVL | ELDGVKASGR |
| 490 | 500 | 510 | |||
| GVDTDIIKAS | VKAFTDALNR | AIVRKEYIIQ | RQEIREEGTV |