O67825

PR
Gene name
infB (aq_2032)
Protein name
Translation initiation factor IF-2
Names
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_2032
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-245 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O67825

Entry ID Method Resolution Chain Position Source
AF-O67825-F1 Predicted AlphaFoldDB

No variants for O67825

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O67825

No associated diseases with O67825

7 regional properties for O67825

Type Name Position InterPro Accession
domain Translational (tr)-type GTP-binding domain 306 - 474 IPR000795
domain Translation elongation factor EFTu-like, domain 2 726 - 792 IPR004161
domain Small GTP-binding protein domain 311 - 466 IPR005225
domain Translation initiation factor IF-2, N-terminal 4 - 60 IPR006847-1
domain Translation initiation factor IF-2, N-terminal 228 - 277 IPR006847-2
domain Translation initiation factor IF- 2, domain 3 580 - 695 IPR023115
domain Translation initiation factor IF-2, domain II 482 - 572 IPR044145

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLTKTKRVS DVAKELGVKS KEIIEFLNEY YPRPDGKPWK ASHGLDEQAL EMIYDAFGIK
70 80 90 100 110 120
EEEEKEEVVT EQAQAPAEVE EKKEEEKKEE VIVEEVVEEK KPEVIVEEIE EKKEEEEKKE
130 140 150 160 170 180
EEKPKKSVEE LIKEILEKKE KEKEKKKVEK ERKEEKVRVV EVKKEERKEE KKEEKKEEEK
190 200 210 220 230 240
PKIKMSKKER EIMRKLEHAV EKEKKKQEKR EKEKKKKEEE VKIIYIPEVI TVRELAELLD
250 260 270 280 290 300
VPANKVIAEL MKRGVLATIN QPVPPEVAVE VAESFGYLAE VKKEEEELEE EALLKEEEER
310 320 330 340 350 360
EEELQPRPPI VVVMGHVDHG KTTLLDRIRK TNVAEREKGG ITQHIGASQV ELPDGRKITF
370 380 390 400 410 420
LDTPGHEAFT TLRARGAKVT DISVLVVAAD DGVMPQTIEA INHAKAFNVP IIVAVNKIDK
430 440 450 460 470 480
PNADPMKVRR ELSEHGLIPE EWGGDTIFVD ISAKTGQNVD QLLEMILLLA DILELKANPN
490 500 510 520 530 540
KKARGTIIES KLDRKRGPVA TVIVEDGTLR VGDHFVAGTT YGRVRAMFDD KGRQVKEAPP
550 560 570 580 590 600
STPVEVLGFE ELPEAGDELI VVDDERTARE IAEKRKEKKE REEKLQTIRL EDIYKKIQTG
610 620 630 640 650 660
ETKELRIVLK TDTMGSLEAL KKSLEELSNE KVQVKIIHGA VGGITENDIM LAKASGAIVI
670 680 690 700 710 720
GFNTRPDPKA RELMEKEKVD VRLYGVIYEA IEDVKKALVG LLEPIKKEEV IGMAEVRATF
730 740 750 760 770 780
KIKKVGTVAG CYVLNGKLVR GAKARLIREG VVIYDGEIES LKRFKEDVQE VTAGYECGVK
790 800
LKDYNDVKVG DQIECYEIRY EKPTL