O67779

PR
Gene name
polA (aq_1967)
Protein name
DNA polymerase I
Names
POL I
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_1967
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

223-292 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O67779

Entry ID Method Resolution Chain Position Source
AF-O67779-F1 Predicted AlphaFoldDB

No variants for O67779

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O67779

No associated diseases with O67779

3 regional properties for O67779

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family A, palm domain 211 - 572 IPR001098
domain 3'-5' exonuclease domain 3 - 162 IPR002562
conserved_site DNA-directed DNA polymerase, family A, conserved site 402 - 421 IPR019760

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

2 GO annotations of biological process

Name Definition
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDFEYVTGEE GLKKAIKRLE NSPYLYLDTE TTGDRIRLVQ IGDEENTYVI DLYEIQDIEP
70 80 90 100 110 120
LRKLINERGI VGHNLKFDLK YLYRYGIFPS ATFDTMIASY LLGYERHSLN HIVSNLLGYS
130 140 150 160 170 180
MDKSYQTSDW GASVLSDAQL KYAANDVIVL RELFPKMRDM LNELDAERGE ELLKTRTAKI
190 200 210 220 230 240
FDLKSPVAIV EMAFVREVAK LEINGFPVDV EELTNKLKAV ERETQKRIQE FYIKYRVDPL
250 260 270 280 290 300
SPKQLASLLT KKFKLNLPKT PKGNVSTDDK ALTSYQDVEP VKLVLEIRKL KKIADKLKEL
310 320 330 340 350 360
KEHLKNGRVY PEFKQIGAVT GRMSSAHPNI QNIHRDMRGI FKAEEGNTFV ISDFSQIELR
370 380 390 400 410 420
IAAEYVKDPL MLDAFKKGKD MHRYTASVVL GKKEEEITKE ERQLAKAINF GLIYGISAKG
430 440 450 460 470 480
LAEYAKLGYG VEISLEEAQV LRERFFKNFK AFKEWHDRVK KELKEKGEVK GHTLLGRRFS
490 500 510 520 530 540
ANTFNDAVNY PIQGTGADLL KLAVLLFDAN LQKKGIDAKL VNLVHDEIVV ECEKEKAEEV
550 560 570
KEILEKSMKT AGKIILKEVP VEVESVINER WTKD