O67766

PR
Gene name
rusA (aq_1953)
Protein name
Crossover junction endodeoxyribonuclease RusA
Names
Holliday junction nuclease RusA, Holliday junction resolvase
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_1953
EC number
3.1.21.10: Endodeoxyribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O67766

Entry ID Method Resolution Chain Position Source
AF-O67766-F1 Predicted AlphaFoldDB

No variants for O67766

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O67766

No associated diseases with O67766

No regional properties for O67766

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O67766

Functions

Description
EC Number 3.1.21.10 Endodeoxyribonucleases producing 5'-phosphomonoesters
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
crossover junction endodeoxyribonuclease activity Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
magnesium ion binding Binding to a magnesium (Mg) ion.

2 GO annotations of biological process

Name Definition
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MISEMEEIEL YLSKLPVPKS NRYIRPKGGK VFKPPRVTNW EARAIWELRE QFKGDAIDYE
70 80 90 100 110 120
ISVDITLILP NRRKRDIDNM LKSLWDVMEK AGVIKNDNLI FEVHTVKKIE KGKEGVIIKI
RPFQSP