O67718

PR
Gene name
secA
Protein name
Protein translocase subunit SecA
Names
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_1870
EC number
7.4.2.8: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

683-752 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O67718

Entry ID Method Resolution Chain Position Source
AF-O67718-F1 Predicted AlphaFoldDB

No variants for O67718

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O67718

No associated diseases with O67718

8 regional properties for O67718

Type Name Position InterPro Accession
domain Helicase, C-terminal 427 - 584 IPR001650
domain SecA DEAD-like, N-terminal 2 - 392 IPR011115
domain SecA Wing/Scaffold 713 - 926 IPR011116
domain SecA, preprotein cross-linking domain 231 - 348 IPR011130
domain Helicase superfamily 1/2, ATP-binding domain 92 - 250 IPR014001
domain SecA motor DEAD 1 - 715 IPR014018
conserved_site SecA conserved site 492 - 507 IPR020937
domain SecA, C-terminal helicase domain 410 - 685 IPR044722

Functions

Description
EC Number 7.4.2.8 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm
  • Distribution is 50-50
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell envelope Sec protein transport complex A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
ABC-type protein transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein-exporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.

4 GO annotations of biological process

Name Definition
intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
protein import The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
protein transport by the Sec complex The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLGWIAKKII GTKNEREVKR LRKFVNQINE LEKELDALTN KELVELAQEL HDKIRFDEEL
70 80 90 100 110 120
KERVIKGEIT PEVIKAFALV REAAKRTLGL RHFDVQLIGG LVLHEGKIAE MKTGEGKTLV
130 140 150 160 170 180
ATSPAVVNGM TDEGVHIVTV NDYLARRDAQ WMGPIYKFLG LEVGVINSDG KTYLVEWVDP
190 200 210 220 230 240
EKVKEAIEND VRVWPKGYYE EILPSEKVNI DAKKTYFTTL KEAEHRRKAY EAHITYGTNN
250 260 270 280 290 300
EFGFDYLRDN LAFSKEEIVQ VKGHNYAIVD EVDSILIDEA RTPLIISGPA QIDSQIYHVA
310 320 330 340 350 360
DAVVRKLKKD KDFTVDEKNR TVNLTEQGIK KVEKMLGIDN LYDLKHVDLL HAILQSIRAH
370 380 390 400 410 420
HLFKKDVHYI VRDGEVLIVD EFTGRVLPGR RWSDGLHQAI EVKEGVPVKE ENQTLASITF
430 440 450 460 470 480
QNYFKLYRKL AGMTGTAETE ALEFKEIYGL DVVVIPTHKP MIRKDHPDLV FKTKEEKWER
490 500 510 520 530 540
VVEEVLLNHI FGRPVLVGTV SIEDNEKLSS LLKNKKLLKE IANRNSFKRR LEETAKNLGV
550 560 570 580 590 600
SPEEVQKKLE EVLKKGIPHN VLNAKHHERE AEIIAQAGRV GAVTIATNMA GRGTDILLGG
610 620 630 640 650 660
NPEYLAKQML KEKGINPEEA TEEQFREALR EAYRITEEEK EKVKKLGGLL VIGTERHESR
670 680 690 700 710 720
RIDNQLRGRA GRQGDPGESR FIVSLEDDLL RLFGGERVSK LMDMLKIERG EPIESRMVSK
730 740 750 760 770 780
ALENAQKRVE AQNFQIRKRL YEFDSVMNIQ RDVVYTLRRQ LLEGENVHEK IKEFLKDIIT
790 800 810 820 830 840
QKVNELLPED DPELWDLEPL KAFLKELTGR EVEIPQVRDK EELIQKLYEE LLKIYEEKEK
850 860 870 880 890 900
EIGSPEAMRE LERVILLNLL DNAWREHLHT LDRLREGIYL RGYAGKDPLI EYKREAYELF
910 920 930 940 950 960
ENMMENVKLN TLMTLFNVQI KSEEEIKEVE HEEEKKHQRL LEEAELQGVQ GKSDKKPRPK
970 980
TLKERLKEER LRKRKLKAKK KEQE