O67691

PR
Gene name
purL
Protein name
Phosphoribosylformylglycinamidine synthase subunit PurL
Names
FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_1836
EC number
6.3.5.3: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O67691

Entry ID Method Resolution Chain Position Source
AF-O67691-F1 Predicted AlphaFoldDB

No variants for O67691

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O67691

No associated diseases with O67691

5 regional properties for O67691

Type Name Position InterPro Accession
domain PurM-like, C-terminal domain 193 - 347 IPR010918-1
domain PurM-like, C-terminal domain 576 - 716 IPR010918-2
domain PurM-like, N-terminal domain 80 - 181 IPR016188-1
domain PurM-like, N-terminal domain 432 - 558 IPR016188-2
domain Phosphoribosylformylglycinamidine synthase, linker domain 8 - 45 IPR041609

Functions

Description
EC Number 6.3.5.3 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MERVWEAYGL TEEEYRKILK TLKREPNHVE LGVLGALWSE HCSYKSSKKH LKKFPTKAEW
70 80 90 100 110 120
VVQGPGENAG VVKIDEKVWV AFKVESHNHP SYIEPFHGAA TGVGGIIRDV LSMGARPIAL
130 140 150 160 170 180
ADSLRFGEFN YHETKRLVKG VVSGISFYGN CIGVPTVAGE TVFEPSYKTN PLVNAFCLGV
190 200 210 220 230 240
IPAGRMYRAR ATREGQLLFL IGSSTGRDGI FGAVMASGEF SEDVEEKRPN VQIGDPYFGK
250 260 270 280 290 300
KLVEAIMEIV EKDLIVGMQD LGAAGLAGSA SEIAAKSEKG VELYLENVPL REKDMNPYEI
310 320 330 340 350 360
LLSESQERML LVVEEENVEK VKEIANKWHL EGAVVGKITD DDTFRAYYKG ELVAELPVSL
370 380 390 400 410 420
IVDEAPVYDR PYKEPEYMKE VRNFNQEELP QTDVKEALKK LLSSPNISCK EWVYTQYDYQ
430 440 450 460 470 480
VGTNTLLIPG HDAAVLRLKW VLRPELTTEK GIAISSEGNG RMVYLNPYEG GKFVVAEVCR
490 500 510 520 530 540
NLACVGAKPL AITDCLNFGN PERPEIMWQF VKAVEGMAEA CEELGIPVVS GNVSLYNETV
550 560 570 580 590 600
EKNEIRNVFP TPIVVGVGVL EKAEKYTPSK VEKESELYLV GNLEENLRLD GSEYLKVIHG
610 620 630 640 650 660
LIKGDVPPVD LEKEKILINL LISFNNKELI TCAHDVSVGG LLIALLEMVF RTPYGLEVEV
670 680 690 700 710 720
YTDERPDVFF FSENPTRVII GVESDKAEEV KNAVEKAGLE WMYIGKTTEE KKIKVTFNGD
730 740
TLLEDELEEY EKLWRTSLEK LLGST