O67606

PR
Gene name
metE
Protein name
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Names
Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_1710
EC number
2.1.1.14: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

370-467 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O67606

Entry ID Method Resolution Chain Position Source
AF-O67606-F1 Predicted AlphaFoldDB

No variants for O67606

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O67606

No associated diseases with O67606

2 regional properties for O67606

Type Name Position InterPro Accession
domain Cobalamin-independent methionine synthase MetE, C-terminal/archaeal 429 - 752 IPR002629
domain Cobalamin-independent methionine synthase MetE, N-terminal 4 - 318 IPR013215

Functions

Description
EC Number 2.1.1.14 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVKTYAFGFP KLGEKREFKR LLENYWKGKI SQEELIKGME ELNLWRANLY RENVEIIPSN
70 80 90 100 110 120
ELSYYDFMLD TTVMVGAIPS RFGEYRGLDT YFEMARGKNA LELTKWFNTN YHYLVPELEG
130 140 150 160 170 180
ENFKLLINRP LEDYKFFKEK GINTVPHVIG LFTFLKLSKA PKRVEEEGLP VIILEKLDTK
190 200 210 220 230 240
ERLEKFTKAL LPVYKELLES LKNEGVNRVH FEEPALVTDL EDYDWEILNE IYSELSKVGV
250 260 270 280 290 300
DLGILTYYDS VSDYDKFVNL PVKALHFDLV SNEENLKNIK EKGFPEDKEL IAGIINGRQP
310 320 330 340 350 360
WRANLREKVK LLEELLKVSA NLVVSNSCPL YHLPVTVEPE DELPEGLKER LSFAKEKLRE
370 380 390 400 410 420
IRLIKEALEG KEEALREVES SEKVMTAVFA QNPEVRRRLA SLSEKDFQRE LPYKERDKIQ
430 440 450 460 470 480
RDILKLPLFP TTTIGSFPQT EDVRKMRTAY RTGKISEEEY KNFIKQKIKY AIEVQEDIGL
490 500 510 520 530 540
DVLVHGEFER SDMVEYFAIK LDGIATTKHG WVLSYGSRVY RPPIIYGDVS RPAPMTLEEI
550 560 570 580 590 600
TYAQSLTNKP VKGMLTGPVT ILNWSYYRED VPKREIAYQI ALALLDEVKD LENAGIKVIQ
610 620 630 640 650 660
IDEPAFREGA PLKKRDWPEY FDWAVKAFRL ASRAKPETQI HTHMCYSEFN EIIEYIYQMD
670 680 690 700 710 720
FDVISIEASR SKGEIIEVFE KFKGWDRQIG IGVYDIHSPA IPTKEEMKAI MLRAMKVLPK
730 740 750 760
ELLWVNPDCG LKTRRWEEVI PALRNMVDMA KELREEVGVK V